Literature DB >> 19406990

Very small embryonic/epiblast-like stem cells: a missing link to support the germ line hypothesis of cancer development?

Mariusz Z Ratajczak1, Dong-Myung Shin, Magda Kucia.   

Abstract

The morphology of several tumors mimics developmentally early tissues, and tumors often express early developmental markers characteristic of the germ line lineage. The presence of these markers in neoplastic cells could reflect the dedifferentiation of somatic cells in which cancer develops or cancer origination in primitive stem cells closely related to the epiblast/germ line. The identification of primitive germ line-derived very small embryonic/epiblast-like stem cells, which are deposited early in embryogenesis in developing organs and persist in several organs into adulthood, raised the possibility that cancer may originate in these cells. In this review, we hypothesize that very small embryonic/epiblast-like stem cells could be a missing link that support the more than 100-year-old concepts of the embryonic rest or germ line origin hypotheses of cancer development; however, further experimental evidence is needed to support this hypothesis.

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Year:  2009        PMID： 19406990      PMCID： PMC2684162          DOI： 10.2353/ajpath.2009.081143

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


  49 in total

Review 1.  Primordial germ cells in the mouse.

Authors:  Anne McLaren
Journal:  Dev Biol       Date:  2003-10-01       Impact factor: 3.582

2.  Derivation of human embryonic germ cells: an alternative source of pluripotent stem cells.

Authors:  Lee Turnpenny; Sarah Brickwood; Cosma M Spalluto; Karen Piper; Iain T Cameron; David I Wilson; Neil A Hanley
Journal:  Stem Cells       Date:  2003       Impact factor: 6.277

3.  Stem cell plasticity revisited: CXCR4-positive cells expressing mRNA for early muscle, liver and neural cells 'hide out' in the bone marrow.

Authors:  M Z Ratajczak; M Kucia; R Reca; M Majka; A Janowska-Wieczorek; J Ratajczak
Journal:  Leukemia       Date:  2004-01       Impact factor: 11.528

4.  Reprogramming of primordial germ cells begins before migration into the genital ridge, making these cells inadequate donors for reproductive cloning.

Authors:  Yukiko Yamazaki; Mellissa R W Mann; Susan S Lee; Joel Marh; John R McCarrey; Ryuzo Yanagimachi; Marisa S Bartolomei
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-23       Impact factor: 11.205

Review 5.  Epigenetic regulation of mammalian genomic imprinting.

Authors:  Katia Delaval; Robert Feil
Journal:  Curr Opin Genet Dev       Date:  2004-04       Impact factor: 5.578

6.  Birth of parthenogenetic mice that can develop to adulthood.

Authors:  Tomohiro Kono; Yayoi Obata; Quiong Wu; Katsutoshi Niwa; Yukiko Ono; Yuji Yamamoto; Eun Sung Park; Jeong-Sun Seo; Hidehiko Ogawa
Journal:  Nature       Date:  2004-04-22       Impact factor: 49.962

Review 7.  Stem cell origin of cancer and differentiation therapy.

Authors:  Stewart Sell
Journal:  Crit Rev Oncol Hematol       Date:  2004-07       Impact factor: 6.312

Review 8.  Uncommon primary mediastinal tumours.

Authors:  Paolo Macchiarini; Helmut Ostertag
Journal:  Lancet Oncol       Date:  2004-02       Impact factor: 41.316

9.  Marrow-isolated adult multilineage inducible (MIAMI) cells, a unique population of postnatal young and old human cells with extensive expansion and differentiation potential.

Authors:  Gianluca D'Ippolito; Sylma Diabira; Guy A Howard; Philippe Menei; Bernard A Roos; Paul C Schiller
Journal:  J Cell Sci       Date:  2004-06-01       Impact factor: 5.285

10.  Serum deprivation of human marrow stromal cells (hMSCs) selects for a subpopulation of early progenitor cells with enhanced expression of OCT-4 and other embryonic genes.

Authors:  Radhika R Pochampally; Jason R Smith; Joni Ylostalo; Darwin J Prockop
Journal:  Blood       Date:  2003-11-20       Impact factor: 22.113
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  19 in total

1.  Adult murine bone marrow-derived very small embryonic-like stem cells differentiate into the hematopoietic lineage after coculture over OP9 stromal cells.

Authors:  Janina Ratajczak; Marcin Wysoczynski; Ewa Zuba-Surma; Wu Wan; Magda Kucia; Mervin C Yoder; Mariusz Z Ratajczak
Journal:  Exp Hematol       Date:  2010-10-27       Impact factor: 3.084

2.  The negative effect of prolonged somatotrophic/insulin signaling on an adult bone marrow-residing population of pluripotent very small embryonic-like stem cells (VSELs).

Authors:  Magda Kucia; Michal Masternak; Riu Liu; Dong-Myung Shin; Janina Ratajczak; Katarzyna Mierzejewska; Adam Spong; John J Kopchick; Andrzej Bartke; Mariusz Z Ratajczak
Journal:  Age (Dordr)       Date:  2012-01-05

Review 3.  Epiblast/germ line hypothesis of cancer development revisited: lesson from the presence of Oct-4+ cells in adult tissues.

Authors:  Mariusz Z Ratajczak; Dong-Myung Shin; Rui Liu; Wojtek Marlicz; Maciej Tarnowski; Janina Ratajczak; Magda Kucia
Journal:  Stem Cell Rev Rep       Date:  2010-06       Impact factor: 5.739

Review 4.  Parental imprinting regulates insulin-like growth factor signaling: a Rosetta Stone for understanding the biology of pluripotent stem cells, aging and cancerogenesis.

Authors:  M Z Ratajczak; D-M Shin; G Schneider; J Ratajczak; M Kucia
Journal:  Leukemia       Date:  2012-11-08       Impact factor: 11.528

5.  A novel insight into aging: are there pluripotent very small embryonic-like stem cells (VSELs) in adult tissues overtime depleted in an Igf-1-dependent manner?

Authors:  Mariusz Z Ratajczak; Dong-Myung Shin; Janina Ratajczak; Magda Kucia; Andrzej Bartke
Journal:  Aging (Albany NY)       Date:  2010-11       Impact factor: 5.682

Review 6.  Very small embryonic-like stem cells (VSELs) represent a real challenge in stem cell biology: recent pros and cons in the midst of a lively debate.

Authors:  M Z Ratajczak; E Zuba-Surma; W Wojakowski; M Suszynska; K Mierzejewska; R Liu; J Ratajczak; D M Shin; M Kucia
Journal:  Leukemia       Date:  2013-09-10       Impact factor: 11.528

Review 7.  THE "-OMAS" and "-OPIAS":  Targeted and Philosophical Considerations Regarding Hamartomas, Choristomas, Teratomas, Ectopias, and Heterotopias in Pediatric Otorhinolaryngologic Pathology.

Authors:  John A Ozolek; Merva Soluk Tekkesin
Journal:  Head Neck Pathol       Date:  2021-03-15

Review 8.  Very small embryonic-like stem cells: implications in reproductive biology.

Authors:  Deepa Bhartiya; Sreepoorna Unni; Seema Parte; Sandhya Anand
Journal:  Biomed Res Int       Date:  2013-02-13       Impact factor: 3.411

9.  Gonadotropin treatment augments postnatal oogenesis and primordial follicle assembly in adult mouse ovaries?

Authors:  Deepa Bhartiya; Kalpana Sriraman; Pranesh Gunjal; Harshada Modak
Journal:  J Ovarian Res       Date:  2012-11-07       Impact factor: 4.234

10.  An intensified systemic trafficking of bone marrow-derived stem/progenitor cells in patients with pancreatic cancer.

Authors:  Teresa Starzyńska; Krzysztof Dąbkowski; Wojciech Błogowski; Ewa Zuba-Surma; Marta Budkowska; Daria Sałata; Barbara Dołęgowska; Wojciech Marlicz; Jerzy Lubikowski; Mariusz Z Ratajczak
Journal:  J Cell Mol Med       Date:  2013-05-15       Impact factor: 5.310
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