Literature DB >> 19406479

MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells.

Eirikur Saeland1, Marein A W P de Jong, Alexey A Nabatov, Hakan Kalay, Teunis B H Geijtenbeek, Yvette van Kooyk.   

Abstract

Mother-to-child transmission of human immunodeficiency virus-1 (HIV-1) occurs frequently via breast-feeding. HIV-1 targets DC-SIGN+ dendritic cells (DCs) in mucosal areas that allow efficient transmission of the virus to T cells. Here, we demonstrate that the epithelial mucin MUC1, abundant in milk, efficiently bound to DC-SIGN on DC. The O-linked glycans within the mucin domain contained Lewis X structures, that were specifically recognized by the receptor. Interestingly, MUC1 prevented DC-SIGN-mediated transmission of HIV-1 from DCs to CD4+ T cells. We hypothesize that repetitive units of Lewis X, within the mucin domain, play an important role in inhibiting transmission of HIV-1 from mother to child.

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Year:  2009        PMID： 19406479     DOI： 10.1016/j.molimm.2009.03.025

Source DB:  PubMed          Journal:  Mol Immunol        ISSN： 0161-5890            Impact factor:   4.407


  37 in total

1.  Breast Milk of HIV-Positive Mothers Has Potent and Species-Specific In Vivo HIV-Inhibitory Activity.

Authors:  Angela Wahl; Caroline Baker; Rae Ann Spagnuolo; Lisa W Stamper; Genevieve G Fouda; Sallie R Permar; Katie Hinde; Louise Kuhn; Lars Bode; Grace M Aldrovandi; J Victor Garcia
Journal:  J Virol       Date:  2015-08-19       Impact factor: 5.103

2.  Exclusive breastfeeding reduces risk of mortality in infants up to 6 mo of age born to HIV-positive Tanzanian women.

Authors:  Uma Chandra Mouli Natchu; Enju Liu; Christopher Duggan; Gernard Msamanga; Karen Peterson; Said Aboud; Donna Spiegelman; Wafaie W Fawzi
Journal:  Am J Clin Nutr       Date:  2012-10-10       Impact factor: 7.045

3.  The Human Glycoprotein Salivary Agglutinin Inhibits the Interaction of DC-SIGN and Langerin with Oral Micro-Organisms.

Authors:  Martine A Boks; Sabrina T G Gunput; Ilona Kosten; Susan Gibbs; Sandra J van Vliet; Antoon J M Ligtenberg; Yvette van Kooyk
Journal:  J Innate Immun       Date:  2016-04-16       Impact factor: 7.349

Review 4.  The impact of the milk glycobiome on the neonate gut microbiota.

Authors:  Alline R Pacheco; Daniela Barile; Mark A Underwood; David A Mills
Journal:  Annu Rev Anim Biosci       Date:  2014-11-05       Impact factor: 8.923

5.  Human milk mucin 1 and mucin 4 inhibit Salmonella enterica serovar Typhimurium invasion of human intestinal epithelial cells in vitro.

Authors:  Bo Liu; Zhuoteng Yu; Ceng Chen; David E Kling; David S Newburg
Journal:  J Nutr       Date:  2012-06-20       Impact factor: 4.798

Review 6.  What infants and breasts can teach us about natural protection from HIV infection.

Authors:  Grace M Aldrovandi; Louise Kuhn
Journal:  J Infect Dis       Date:  2010-11-01       Impact factor: 5.226

Review 7.  The mouth: a gateway or a trap for HIV?

Authors:  Daniel Malamud; Sharon M Wahl
Journal:  AIDS       Date:  2010-01-02       Impact factor: 4.177

Review 8.  The oral mucosa immune environment and oral transmission of HIV/SIV.

Authors:  Lianna F Wood; Ann Chahroudi; Hui-Ling Chen; Heather B Jaspan; Donald L Sodora
Journal:  Immunol Rev       Date:  2013-07       Impact factor: 12.988

Review 9.  Immunology of pediatric HIV infection.

Authors:  Nicole H Tobin; Grace M Aldrovandi
Journal:  Immunol Rev       Date:  2013-07       Impact factor: 12.988

10.  Oncolytic vesicular stomatitis virus in an immunocompetent model of MUC1-positive or MUC1-null pancreatic ductal adenocarcinoma.

Authors:  Eric Hastie; Dahlia M Besmer; Nirav R Shah; Andrea M Murphy; Megan Moerdyk-Schauwecker; Carlos Molestina; Lopamudra Das Roy; Jennifer M Curry; Pinku Mukherjee; Valery Z Grdzelishvili
Journal:  J Virol       Date:  2013-07-17       Impact factor: 5.103
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