OBJECTIVE: Obesity is an important factor that might reduce fecundity. In order to determine the underlying physiological mechanisms and risk factors, the obesity-fecundity association is investigated in relation to parity, menstrual cycle regularity, smoking habits, and age. METHODS: This was a retrospective cohort study of 22,840 women who gave birth between January 2006 and January 2007 in the Dr Zekai Tahir Burak Women's Health Research and Education Hospital. Age, parity, prepregnancy body mass index (BMI) values, time to pregnancy data related to smoking, and reproductive, medical, and gynecological history were obtained from the medical records. RESULTS: Fecundity was reduced for overweight and obese women compared with optimal weight women, and this reduction was more evident for obese primiparous women. Fecundity remained reduced for overweight and obese women with normal menstrual cycles. Obese and overweight women were found to smoke significantly more than the optimal weight group. CONCLUSIONS: Obesity was found to be associated with reduced fecundity for all weight-adjusted groups of women and persisted for women with regular cycles. Weight loss should be encouraged initially during the treatment of infertile overweight and obese women.
OBJECTIVE:Obesity is an important factor that might reduce fecundity. In order to determine the underlying physiological mechanisms and risk factors, the obesity-fecundity association is investigated in relation to parity, menstrual cycle regularity, smoking habits, and age. METHODS: This was a retrospective cohort study of 22,840 women who gave birth between January 2006 and January 2007 in the Dr Zekai Tahir Burak Women's Health Research and Education Hospital. Age, parity, prepregnancy body mass index (BMI) values, time to pregnancy data related to smoking, and reproductive, medical, and gynecological history were obtained from the medical records. RESULTS: Fecundity was reduced for overweight and obesewomen compared with optimal weight women, and this reduction was more evident for obese primiparous women. Fecundity remained reduced for overweight and obesewomen with normal menstrual cycles. Obese and overweight women were found to smoke significantly more than the optimal weight group. CONCLUSIONS:Obesity was found to be associated with reduced fecundity for all weight-adjusted groups of women and persisted for women with regular cycles. Weight loss should be encouraged initially during the treatment of infertile overweight and obesewomen.
Authors: Michele L Susko; Michael S Bloom; Iulia A Neamtiu; Allison A Appleton; Simona Surdu; Cristian Pop; Edward F Fitzgerald; Doru Anastasiu; Eugen S Gurzau Journal: Environ Res Date: 2017-01-03 Impact factor: 6.498
Authors: Julia Kim; Caroline Juneau; George Patounakis; Scott Morin; Shelby Neal; Emre Seli; Richard Scott Journal: J Assist Reprod Genet Date: 2020-08-22 Impact factor: 3.412
Authors: Tessa M van Elten; Matty D A Karsten; Anouk Geelen; Anne M van Oers; Mireille N M van Poppel; Henk Groen; Reinoud J B J Gemke; Ben Willem Mol; Meike A Q Mutsaerts; Tessa J Roseboom; Annemieke Hoek Journal: PLoS One Date: 2018-11-07 Impact factor: 3.240
Authors: Reinaldo S A Sasaki; Mário S Approbato; Mônica C S Maia; Eliamar A B Fleury E Ferreira; Neuma Zanluchi Journal: JBRA Assist Reprod Date: 2019-01-31