INTRODUCTION: Postpartum cerebral angiopathy (PPA) is considered one of a diverse group of rare conditions termed "reversible cerebral vasoconstriction syndromes". Existing literature suggest considerable overlap in the manifestations of eclampsia and PPA. METHODS: Retrospective case series review of PPA and eclampsia from a single neurosciences intensive care unit patient log identified over a consecutive 18-month period. A MEDLINE search (using OVID) of the English literature from 1950 through October 2008 was also performed. RESULTS: Four patients who meet the obstetrical criteria for eclampsia and four patients whose clinical and radiographic features were consistent with PPA were identified. Twenty-eight patients with PPA were identified from the literature and showed significant clinical and radiographic overlap without cohort. CONCLUSION: Given the overlapping clinical, laboratory, and radiographical features of eclampsia and PPA, it is probable they share a similar underlying pathophysiological mechanism and represent different clinical expressions of the same pregnancy-related disorder. The obstetrical definition of eclampsia may be to strict when applied in the neurosciences intensive care unit.
INTRODUCTION: Postpartum cerebral angiopathy (PPA) is considered one of a diverse group of rare conditions termed "reversible cerebral vasoconstriction syndromes". Existing literature suggest considerable overlap in the manifestations of eclampsia and PPA. METHODS: Retrospective case series review of PPA and eclampsia from a single neurosciences intensive care unit patient log identified over a consecutive 18-month period. A MEDLINE search (using OVID) of the English literature from 1950 through October 2008 was also performed. RESULTS: Four patients who meet the obstetrical criteria for eclampsia and four patients whose clinical and radiographic features were consistent with PPA were identified. Twenty-eight patients with PPA were identified from the literature and showed significant clinical and radiographic overlap without cohort. CONCLUSION: Given the overlapping clinical, laboratory, and radiographical features of eclampsia and PPA, it is probable they share a similar underlying pathophysiological mechanism and represent different clinical expressions of the same pregnancy-related disorder. The obstetrical definition of eclampsia may be to strict when applied in the neurosciences intensive care unit.
Authors: Romergryko G Geocadin; Alexander Y Razumovsky; Robert J Wityk; Anish Bhardwaj; John A Ulatowski Journal: J Neurol Sci Date: 2002-12-15 Impact factor: 3.181
Authors: Laura A Matthys; Kristin H Coppage; Donna S Lambers; John R Barton; Baha M Sibai Journal: Am J Obstet Gynecol Date: 2004-05 Impact factor: 8.661
Authors: Benjamin Matosevic; Martin Furtner; Michael Knoflach; Christoph Schmidauer; Georg Wille; Thaddaeus Gotwald; Stefan Kiechl; Johann Willeit Journal: Neurol Int Date: 2010-11-26