Literature DB >> 1940477

Virulence of rimantadine-resistant human influenza A (H3N2) viruses in ferrets.

C Sweet1, F G Hayden, K J Jakeman, S Grambas, A J Hay.   

Abstract

The influence of rimantadine-resistance mutations on the virulence of human H3N2 viruses in ferrets was examined. The similarities in virulence of the drug-resistant mutants with single amino acid substitutions at three different locations, 27, 30, and 31, within the M2 sequence and their corresponding sensitive wild-type isolates contrasted with differences in virulence between the three pairs of viruses. These data provide further evidence that rimantadine-resistant viruses that emerge during treatment of patients with the drug are unaltered both in their growth characteristics and virulence.

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Year:  1991        PMID： 1940477     DOI： 10.1093/infdis/164.5.969

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  18 in total

1.  Evolution, safety, and highly pathogenic influenza viruses.

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2.  Generation and characterization of recombinant influenza A (H1N1) viruses harboring amantadine resistance mutations.

Authors:  Yacine Abed; Nathalie Goyette; Guy Boivin
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3.  Characterization of the complete genome of influenza A (H5N1) virus isolated during the 2006 outbreak in poultry in India.

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Review 4.  Antiviral therapy: current concepts and practices.

Authors:  B Bean
Journal:  Clin Microbiol Rev       Date:  1992-04       Impact factor: 26.132

5.  Oral administration of cyclopentane neuraminidase inhibitors protects ferrets against influenza virus infection.

Authors:  Clive Sweet; Kenneth J Jakeman; Karen Bush; Pamela C Wagaman; Linda A McKown; Anthony J Streeter; Daksha Desai-Krieger; Pooran Chand; Yarlagadda S Babu
Journal:  Antimicrob Agents Chemother       Date:  2002-04       Impact factor: 5.191

6.  Detection of adamantane-resistant influenza on a microarray.

Authors:  Michael B Townsend; James A Smagala; Erica D Dawson; Varough Deyde; Larisa Gubareva; Alexander I Klimov; Robert D Kuchta; Kathy L Rowlen
Journal:  J Clin Virol       Date:  2008-03-04       Impact factor: 3.168

7.  4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid is a highly effective inhibitor both of the sialidase (neuraminidase) and of growth of a wide range of influenza A and B viruses in vitro.

Authors:  J M Woods; R C Bethell; J A Coates; N Healy; S A Hiscox; B A Pearson; D M Ryan; J Ticehurst; J Tilling; S M Walcott
Journal:  Antimicrob Agents Chemother       Date:  1993-07       Impact factor: 5.191

8.  Influenza A virus acquires enhanced pathogenicity and transmissibility after serial passages in swine.

Authors:  Kai Wei; Honglei Sun; Zhenhong Sun; Yipeng Sun; Weili Kong; Juan Pu; Guangpeng Ma; Yanbo Yin; Hanchun Yang; Xin Guo; Kin-Chow Chang; Jinhua Liu
Journal:  J Virol       Date:  2014-08-06       Impact factor: 5.103

9.  Treatment of influenza A (H1N1) virus infections in mice and ferrets with cyanovirin-N.

Authors:  Donald F Smee; Kevin W Bailey; Min-Hui Wong; Barry R O'Keefe; Kirk R Gustafson; Vasiliy P Mishin; Larisa V Gubareva
Journal:  Antiviral Res       Date:  2008-07-02       Impact factor: 5.970

10.  Efficacy of 2'-deoxy-2'-fluororibosides against influenza A and B viruses in ferrets.

Authors:  K J Jakeman; M Tisdale; S Russell; A Leone; C Sweet
Journal:  Antimicrob Agents Chemother       Date:  1994-08       Impact factor: 5.191
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