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Literature DB >> 19404336

SCAI blocks MAL-evolent effects on cancer cell invasion.

Abstract

SCAI is a newly discovered protein that reduces cancer cell invasiveness. SCAI inhibits the MAL/SRF transcriptional activator complex that is downstream of Rho GTPase and actin, resulting in reduced expression of beta1-integrins and loss of invasive potential.

Entities: Disease Gene

Mesh：

Substances：

Year: 2009 PMID： 19404336 DOI： 10.1038/ncb0509-540

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

12 in total

Review 1. The hallmarks of cancer.

Authors: D Hanahan; R A Weinberg
Journal: Cell Date: 2000-01-07 Impact factor: 41.582

2. Actin dynamics control SRF activity by regulation of its coactivator MAL.

Authors: Francesc Miralles; Guido Posern; Alexia-Ileana Zaromytidou; Richard Treisman
Journal: Cell Date: 2003-05-02 Impact factor: 41.582

Review 3. PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation.

Authors: Zhou-shen Zhao; Ed Manser
Journal: Biochem J Date: 2005-03-01 Impact factor: 3.857

Review 4. beta 1 integrin function in vivo: adhesion, migration and more.

Authors: C Brakebusch; R Fässler
Journal: Cancer Metastasis Rev Date: 2005-09 Impact factor: 9.264

Review 5. Actin' together: serum response factor, its cofactors and the link to signal transduction.

Authors: Guido Posern; Richard Treisman
Journal: Trends Cell Biol Date: 2006-10-10 Impact factor: 20.808

6. Increased beta1 integrin is associated with decreased survival in invasive breast cancer.

Authors: Evelyn S Yao; Hui Zhang; Yunn-Yi Chen; Brian Lee; Karen Chew; Dan Moore; Catherine Park
Journal: Cancer Res Date: 2007-01-15 Impact factor: 12.701

Review 7. Roles of Rho-family GTPases in cell polarisation and directional migration.

Authors: Masaki Fukata; Masato Nakagawa; Kozo Kaibuchi
Journal: Curr Opin Cell Biol Date: 2003-10 Impact factor: 8.382

8. SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin.

Authors: Dominique T Brandt; Christian Baarlink; Thomas M Kitzing; Elisabeth Kremmer; Johanna Ivaska; Peter Nollau; Robert Grosse
Journal: Nat Cell Biol Date: 2009-04-06 Impact factor: 28.824

Review 9. Integrin signalling during tumour progression.

Authors: Wenjun Guo; Filippo G Giancotti
Journal: Nat Rev Mol Cell Biol Date: 2004-10 Impact factor: 94.444

10. Nuclear actin regulates dynamic subcellular localization and activity of the SRF cofactor MAL.

Authors: Maria K Vartiainen; Sebastian Guettler; Banafshe Larijani; Richard Treisman
Journal: Science Date: 2007-06-22 Impact factor: 47.728

4 in total

1. The role of miR-766-5p in cell migration and invasion in colorectal cancer.

Authors: Bin Jia; Lei Xia; Fang Cao
Journal: Exp Ther Med Date: 2018-01-08 Impact factor: 2.447

2. MiR-1228 promotes breast cancer cell growth and metastasis through targeting SCAI protein.

Authors: Luoqiang Lin; Dan Liu; Hongyan Liang; Li Xue; Changlei Su; Ming Liu
Journal: Int J Clin Exp Pathol Date: 2015-06-01

3. MiR-625-3p promotes cell migration and invasion via inhibition of SCAI in colorectal carcinoma cells.

Authors: Hailun Zheng; Renqiang Ma; Qizhi Wang; Pei Zhang; Dapeng Li; Qiangwu Wang; Jianchao Wang; Huabin Li; Hao Liu; Zhiwei Wang
Journal: Oncotarget Date: 2015-09-29

4. MiR-425-5p promotes invasion and metastasis of hepatocellular carcinoma cells through SCAI-mediated dysregulation of multiple signaling pathways.

Authors: Feng Fang; Tianqiang Song; Ti Zhang; Yunlong Cui; Gewen Zhang; Qingqing Xiong
Journal: Oncotarget Date: 2017-05-09

4 in total