Literature DB >> 19404202

Severe hepatitis associated with the use of black cohosh: a report of two cases and an advice for caution.

Sophie Pierard1, Jean-Charles Coche, Philippe Lanthier, Xavier Dekoninck, Nicolas Lanthier, Jacques Rahier, André P Geubel.   

Abstract

In spite of the fact that severe side effects have been reported, black cohosh [Actaea racemosa (syn. Cimifuga racemosa)] is likely to be one of the most popular herbs used in the treatment of postmenopausal symptoms and menstrual dysfunction. We report the cases of two patients, one with submassive liver necrosis and the other with chronic hepatitis most likely related to the use of two different preparations containing black cohosh. This represents another advice for caution concerning this popular preparation of inconsistent therapeutic value.

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Year:  2009        PMID： 19404202     DOI： 10.1097/MEG.0b013e3283155451

Source DB:  PubMed          Journal:  Eur J Gastroenterol Hepatol        ISSN： 0954-691X            Impact factor:   2.566


  6 in total

1.  Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells.

Authors:  Ji-Eun Seo; Xiaoqing Guo; Dayton M Petibone; Sharon D Shelton; Ying Chen; Xilin Li; Volodymyr Tryndyak; Stephanie L Smith-Roe; Kristine L Witt; Nan Mei; Mugimane G Manjanatha
Journal:  Toxicol Sci       Date:  2021-07-16       Impact factor: 4.849

2.  An ethanolic extract of black cohosh causes hematological changes but not estrogenic effects in female rodents.

Authors:  Minerva Mercado-Feliciano; Michelle C Cora; Kristine L Witt; Courtney A Granville; Milton R Hejtmancik; Laurene Fomby; Katherine A Knostman; Michael J Ryan; Retha Newbold; Cynthia Smith; Paul M Foster; Molly K Vallant; Matthew D Stout
Journal:  Toxicol Appl Pharmacol       Date:  2012-06-09       Impact factor: 4.219

3.  Oral complementary medicine and alternative practitioner use varies across chronic conditions and attitudes to risk.

Authors:  Robert J Adams; Sarah L Appleton; Antonia Cole; Tiffany K Gill; Anne W Taylor; Catherine L Hill
Journal:  Clin Epidemiol       Date:  2010-11-08       Impact factor: 4.790

4.  Immunomodulatory effects of black cohosh (Actaea racemosa) extract in female B6C3F1/N mice.

Authors:  Matthew J Smith; Dori R Germolec; Rachel P Frawley; Kimber L White
Journal:  Toxicology       Date:  2013-04-06       Impact factor: 4.221

5.  An overview of the evidence and mechanisms of herb-drug interactions.

Authors:  Pius S Fasinu; Patrick J Bouic; Bernd Rosenkranz
Journal:  Front Pharmacol       Date:  2012-04-30       Impact factor: 5.810

6.  Black Cohosh Hepatotoxicity with Autoimmune Hepatitis Presentation.

Authors:  Diana L Franco; Santosh Kale; Dora M Lam-Himlin; M Edwyn Harrison
Journal:  Case Rep Gastroenterol       Date:  2017-01-27
  6 in total

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