Literature DB >> 19402934

Preliminary evidence for progressive prefrontal abnormalities in adolescents and young adults with bipolar disorder.

Jessica H Kalmar1, Fei Wang, Linda Spencer, Erin Edmiston, Cheryl M Lacadie, Andrés Martin, R Todd Constable, James S Duncan, Lawrence H Staib, Xenophon Papademetris, Hilary P Blumberg.   

Abstract

Previous cross-sectional study of ventral prefrontal cortex (VPFC) implicated progressive volume abnormalities during adolescence in bipolar disorder (BD). In the present study, a within-subject, longitudinal design was implemented to examine brain volume changes during adolescence/young adulthood. We hypothesized that VPFC volume decreases over time would be greater in adolescents/young adults with BD than in healthy comparison adolescents/young adults. Eighteen adolescents/young adults (10 with BD I and 8 healthy comparison participants) underwent two high-resolution magnetic resonance imaging scans over approximately 2 years. Regional volume changes over time were measured. Adolescents/young adults with BD displayed significantly greater volume loss over time, compared to healthy comparison participants, in a region encompassing VPFC and rostral PFC and extending to rostral anterior cingulate cortex (p < .05). Additional areas where volume change differed between groups were observed. While data should be interpreted cautiously due to modest sample size, this study provides preliminary evidence to support the presence of accelerated loss in VPFC and rostral PFC volume in adolescents/young adults with BD.

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Year:  2009        PMID： 19402934      PMCID： PMC2852397          DOI： 10.1017/S1355617709090584

Source DB:  PubMed          Journal:  J Int Neuropsychol Soc        ISSN： 1355-6177            Impact factor:   2.892


  37 in total

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  33 in total

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