| Literature DB >> 19402694 |
Jasper Dinkelaar1, Henrik Gold, Herman S Overkleeft, Jeroen D C Codée, Gijsbert A van der Marel.
Abstract
An efficient synthetic strategy toward a hyaluronic acid (HA) tri-, penta-, and heptamer having a glucosamine-reducing end is reported. The synthesis is based on a glucuronate ester thioglycoside and a trifluoro-N-phenylimidate glucosamine building block. The HA-fragments are synthesized using an S-phenyl GlcN-GluA building block through a combination of chemoselective and one-pot condensation strategies.Entities:
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Year: 2009 PMID： 19402694 DOI： 10.1021/jo9003713
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354