INTRODUCTION: The aim of this study was to describe a pediatric case series of Chikungunya infection associated with extensive bullous skin lesions, a severe and unknown form of the disease, during the 2005-2006 outbreak in La Réunion Island. MATERIALS AND METHODS: Retrospective descriptive hospital-based study in children presenting blisters > or = 10% of total body surface area with laboratory-confirmed Chikungunya infection. RESULTS: Eight boys and five girls with a mean age of 3.4 months were included. Blistering began after an average of 2 days after onset of fever and affected 21.5% (10% to 35%) of the total body surface area. Reverse transcription-polymerase chain reaction of blister fluid (n = 5) was positive with a mean viral load sometimes higher than in concurrent serum. Histopathologic examination (n = 10) showed intraepidermal blisters. Hospitalization and repeated dressing changes under general anesthesia were required. No death occurred. On follow-up, long term repigmentation was excellent with sometimes cosmetic sequelae. CONCLUSION: Chikungunya should be included in the differential diagnosis of febrile blistering dermatoses in small infants in epidemic areas.
INTRODUCTION: The aim of this study was to describe a pediatric case series of Chikungunya infection associated with extensive bullous skin lesions, a severe and unknown form of the disease, during the 2005-2006 outbreak in La Réunion Island. MATERIALS AND METHODS: Retrospective descriptive hospital-based study in children presenting blisters > or = 10% of total body surface area with laboratory-confirmed Chikungunya infection. RESULTS: Eight boys and five girls with a mean age of 3.4 months were included. Blistering began after an average of 2 days after onset of fever and affected 21.5% (10% to 35%) of the total body surface area. Reverse transcription-polymerase chain reaction of blister fluid (n = 5) was positive with a mean viral load sometimes higher than in concurrent serum. Histopathologic examination (n = 10) showed intraepidermal blisters. Hospitalization and repeated dressing changes under general anesthesia were required. No death occurred. On follow-up, long term repigmentation was excellent with sometimes cosmetic sequelae. CONCLUSION: Chikungunya should be included in the differential diagnosis of febrile blistering dermatoses in small infants in epidemic areas.
Authors: G Rezza; L Nicoletti; R Angelini; R Romi; A C Finarelli; M Panning; P Cordioli; C Fortuna; S Boros; F Magurano; G Silvi; P Angelini; M Dottori; M G Ciufolini; G C Majori; A Cassone Journal: Lancet Date: 2007-12-01 Impact factor: 79.321
Authors: Tyler M Sharp; Kyle R Ryff; Luisa Alvarado; Wun-Ju Shieh; Sherif R Zaki; Harold S Margolis; Brenda Rivera-Garcia Journal: J Infect Dis Date: 2016-12-15 Impact factor: 5.226
Authors: Mariola Mascarenhas; Sophiya Garasia; Philippe Berthiaume; Tricia Corrin; Judy Greig; Victoria Ng; Ian Young; Lisa Waddell Journal: PLoS One Date: 2018-11-29 Impact factor: 3.240
Authors: Brad A Goupil; Margaret A McNulty; Matthew J Martin; Michael K McCracken; Rebecca C Christofferson; Christopher N Mores Journal: PLoS One Date: 2016-05-16 Impact factor: 3.240