AIM: To determine the efficacy of perioperative parecoxib injection on postoperative pain reliefafter laparoscopic cholecystectomy. METHODS: A prospective, double-blind, randomized, placebo-controlled study was conducted on 70 patients who underwent elective laparoscopic cholecystectomy under general anesthesia at Siriraj Hospital, Bangkok, from January 2006 to December 2007. Patients were randomized to receive either 20 mg parecoxib infusion 30 min before induction of anesthesia and at 12 h after the first dose (treatment group), or normal saline infusion, in the same schedule, as a placebo (control group). The degree of the postoperative pain was assessed every 3 h in the first 24 h after surgery, and then every 12 h the following day, using a visual analog scale. The consumption of analgesics was also recorded. RESULTS: There were 40 patients in the treatment group, and 30 patients in the control group. The pain scores at each time point, and analgesic consumption did not differ between the two groups. However, there were fewer patients in the treatment group than placebo group who required opioid infusion within the first 24 h (60% vs 37%, P = 0.053). CONCLUSION: Perioperative administration of parecoxib provided no significant effect on postoperative pain reliefafter laparoscopic cholecystectomy. However, preoperative infusion 20 mg parecoxib could significantly reduce the postoperative opioid consumption.
RCT Entities:
AIM: To determine the efficacy of perioperative parecoxib injection on postoperative pain relief after laparoscopic cholecystectomy. METHODS: A prospective, double-blind, randomized, placebo-controlled study was conducted on 70 patients who underwent elective laparoscopic cholecystectomy under general anesthesia at Siriraj Hospital, Bangkok, from January 2006 to December 2007. Patients were randomized to receive either 20 mg parecoxib infusion 30 min before induction of anesthesia and at 12 h after the first dose (treatment group), or normal saline infusion, in the same schedule, as a placebo (control group). The degree of the postoperative pain was assessed every 3 h in the first 24 h after surgery, and then every 12 h the following day, using a visual analog scale. The consumption of analgesics was also recorded. RESULTS: There were 40 patients in the treatment group, and 30 patients in the control group. The pain scores at each time point, and analgesic consumption did not differ between the two groups. However, there were fewer patients in the treatment group than placebo group who required opioid infusion within the first 24 h (60% vs 37%, P = 0.053). CONCLUSION: Perioperative administration of parecoxib provided no significant effect on postoperative pain relief after laparoscopic cholecystectomy. However, preoperative infusion 20 mg parecoxib could significantly reduce the postoperative opioid consumption.
Authors: P A E Puolakka; A I E Puura; R A Pirhonen; A U Ranta; V Autio; L Lindgren; M G F Rorarius Journal: Acta Anaesthesiol Scand Date: 2006-09 Impact factor: 2.105
Authors: Girish P Joshi; Eugene R Viscusi; Tong J Gan; Harold Minkowitz; Mark Cippolle; Rienhard Schuller; Raymond Y Cheung; John G Fort Journal: Anesth Analg Date: 2004-02 Impact factor: 5.108
Authors: Tong J Gan; Girish P Joshi; Eugene Viscusi; Raymond Y Cheung; William Dodge; John G Fort; Connie Chen Journal: Anesth Analg Date: 2004-06 Impact factor: 5.108
Authors: Shengping Lin; Jie Hua; Bin Xu; Tingsong Yang; Zhigang He; Chenglei Xu; Hongbo Meng; Bo Zhou; Zhenshun Song Journal: Int J Clin Exp Med Date: 2015-08-15