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Literature DB >> 19399616

Upregulation and CpG island hypomethylation of the TRF2 gene in human gastric cancer.

Wenjie Dong¹, Lifu Wang, Xiaobing Chen, Pinghu Sun, Yunlin Wu.

Abstract

The telomere-binding protein TRF2 regulates both telomere protection and telomere length. The fact that TRF2 is up-regulated in some tumors indicates that TRF2 plays a role in cancer. However, the role of TRF2 in gastric cancer has not been fully understood. The aim of this study is to evaluate the expression pattern of TRF2 in gastric cancer and examine the potential mechanism of TRF2 regulation. Our study revealed that the expression of TRF2 analyzed by immunohistochemistry was significantly higher in gastric cancers compared to noncancerous tissues. Moreover, TRF2 methylation was detected in six of 30 (20%) primary gastric cancers and 18 of 30 (60%) paired normal tissues, and the downregulation of TRF2 was strongly correlated with the methylation status (P < 0.001). Our results suggest that hypomethylation might contribute to the upregulation of TRF2 in gastric cancers and this overexpression may play a role in the pathogenesis of gastric cancers.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2009 PMID： 19399616 DOI： 10.1007/s10620-009-0810-8

Source DB: PubMed Journal: Dig Dis Sci ISSN： 0163-2116 Impact factor: 3.199

16 in total

1. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres.

Authors: X D Zhu; B Küster; M Mann; J H Petrini; T de Lange
Journal: Nat Genet Date: 2000-07 Impact factor: 38.330

2. Telomeres: more than chromosomal non-sticking ends.

Authors: A L Kierszenbaum
Journal: Mol Reprod Dev Date: 2000-09 Impact factor: 2.609

3. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2.

Authors: J Karlseder; D Broccoli; Y Dai; S Hardy; T de Lange
Journal: Science Date: 1999-02-26 Impact factor: 47.728

4. Telomeric localization of TRF2, a novel human telobox protein.

Authors: T Bilaud; C Brun; K Ancelin; C E Koering; T Laroche; E Gilson
Journal: Nat Genet Date: 1997-10 Impact factor: 38.330

5. Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage.

Authors: Paul S Bradshaw; Dimitrios J Stavropoulos; M Stephen Meyn
Journal: Nat Genet Date: 2005-01-23 Impact factor: 38.330

6. Identification of human Rap1: implications for telomere evolution.

Authors: B Li; S Oestreich; T de Lange
Journal: Cell Date: 2000-05-26 Impact factor: 41.582

7. Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis.

Authors: Raquel Blanco; Purificación Muñoz; Juana M Flores; Peter Klatt; María A Blasco
Journal: Genes Dev Date: 2007-01-15 Impact factor: 11.361

8. NGALR is overexpressed and regulated by hypomethylation in esophageal squamous cell carcinoma.

Authors: Lei Cui; Li-Yan Xu; Zhong-Ying Shen; Qian Tao; Shu-Ying Gao; Zhuo Lv; Ze-Peng Du; Wang-Kai Fang; En-Min Li
Journal: Clin Cancer Res Date: 2008-12-01 Impact factor: 12.531

Review 9. Shelterin: the protein complex that shapes and safeguards human telomeres.

Authors: Titia de Lange
Journal: Genes Dev Date: 2005-09-15 Impact factor: 12.890

10. The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response.

Authors: Jan Karlseder; Kristina Hoke; Olga K Mirzoeva; Christopher Bakkenist; Michael B Kastan; John H J Petrini; Titia de Lange
Journal: PLoS Biol Date: 2004-08-17 Impact factor: 8.029

8 in total

1. Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway.

Authors: Irmina Diala; Nicole Wagner; Frédérique Magdinier; Marina Shkreli; Maria Sirakov; Serge Bauwens; Caroline Schluth-Bolard; Thomas Simonet; Valérie M Renault; Jing Ye; Abdelnnadir Djerbi; Pascal Pineau; Jinkuk Choi; Steven Artandi; Anne Dejean; Michelina Plateroti; Eric Gilson
Journal: EMBO Rep Date: 2013-02-22 Impact factor: 8.807

2. TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells.

Authors: Annamaria Biroccio; Julien Cherfils-Vicini; Adeline Augereau; Sébastien Pinte; Serge Bauwens; Jing Ye; Thomas Simonet; Béatrice Horard; Karine Jamet; Ludovic Cervera; Aaron Mendez-Bermudez; Delphine Poncet; Renée Grataroli; Claire T'kint de Rodenbeeke; Erica Salvati; Angela Rizzo; Pasquale Zizza; Michelle Ricoul; Céline Cognet; Thomas Kuilman; Helene Duret; Florian Lépinasse; Jacqueline Marvel; Els Verhoeyen; François-Loïc Cosset; Daniel Peeper; Mark J Smyth; Arturo Londoño-Vallejo; Laure Sabatier; Vincent Picco; Gilles Pages; Jean-Yves Scoazec; Antonella Stoppacciaro; Carlo Leonetti; Eric Vivier; Eric Gilson
Journal: Nat Cell Biol Date: 2013-06-23 Impact factor: 28.824

3. Gene expression levels of human shelterin complex and shelterin-associated factors regulated by the topoisomerase II inhibitors doxorubicin and etoposide in human cultured cells.

Authors: Masahiro Kato; Masahiro Nakayama; Minako Agata; Kenichi Yoshida
Journal: Tumour Biol Date: 2012-12-18

Review 8. Abnormal function of telomere protein TRF2 induces cell mutation and the effects of environmental tumor‑promoting factors (Review).

Authors: Zhengyi Wang; Xiaoying Wu
Journal: Oncol Rep Date: 2021-07-19 Impact factor: 3.906