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Literature DB >> 19399597

Post-translational modifications of ATP synthase in the heart: biology and function.

Abstract

The ATP synthase complex is a critical enzyme in the energetic pathways of cells because it is the enzyme complex that produces the majority of cellular ATP. It has been shown to be involved in several cardiac phenotypes including heart failure and preconditioning, a cellular protective mechanism. Understanding the regulation of this enzyme is important in understanding the mechanisms behind these important phenomena. Recently there have been several post-translational modifications (PTM) reported for various subunits of this enzyme complex, opening up the possibility of differential regulation by these PTMs. Here we discuss the known PTMs in the heart and other mammalian tissues and their implication to function and regulation of the ATP synthase.

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Year: 2009 PMID： 19399597 PMCID： PMC2905846 DOI： 10.1007/s10863-009-9218-6

Source DB: PubMed Journal: J Bioenerg Biomembr ISSN： 0145-479X Impact factor: 2.945

40 in total

1. Oxidative post-translational modification of tryptophan residues in cardiac mitochondrial proteins.

Authors: Steven W Taylor; Eoin Fahy; James Murray; Roderick A Capaldi; Soumitra S Ghosh
Journal: J Biol Chem Date: 2003-04-04 Impact factor: 5.157

Review 2. Functions of site-specific histone acetylation and deacetylation.

Authors: Mona D Shahbazian; Michael Grunstein
Journal: Annu Rev Biochem Date: 2007 Impact factor: 23.643

3. Quantitative analysis of both protein expression and serine / threonine post-translational modifications through stable isotope labeling with dithiothreitol.

Authors: Keith Vosseller; Kirk C Hansen; Robert J Chalkley; Jonathan C Trinidad; Lance Wells; Gerald W Hart; Alma L Burlingame
Journal: Proteomics Date: 2005-02 Impact factor: 3.984

4. Proteome analysis reveals phosphorylation of ATP synthase beta -subunit in human skeletal muscle and proteins with potential roles in type 2 diabetes.

Authors: Kurt Højlund; Krzysztof Wrzesinski; Peter Mose Larsen; Stephen J Fey; Peter Roepstorff; Aase Handberg; Flemming Dela; Jørgen Vinten; James G McCormack; Christine Reynet; Henning Beck-Nielsen
Journal: J Biol Chem Date: 2003-01-16 Impact factor: 5.157

Review 5. Regulatory mechanisms of proton-translocating F(O)F (1)-ATP synthase.

Authors: Boris A Feniouk; Masasuke Yoshida
Journal: Results Probl Cell Differ Date: 2008

6. Excessive ATP hydrolysis in ischemic myocardium by mitochondrial F1F0-ATPase: effect of selective pharmacological inhibition of mitochondrial ATPase hydrolase activity.

Authors: Gary J Grover; Karnail S Atwal; Paul G Sleph; Feng-Li Wang; Hossain Monshizadegan; Thomas Monticello; David W Green
Journal: Am J Physiol Heart Circ Physiol Date: 2004-10 Impact factor: 4.733

Review 7. Transport ATPases into the year 2008: a brief overview related to types, structures, functions and roles in health and disease.

Authors: Peter L Pedersen
Journal: J Bioenerg Biomembr Date: 2007-12 Impact factor: 2.945

Review 8. Chemical mechanisms of histone lysine and arginine modifications.

Authors: Brian C Smith; John M Denu
Journal: Biochim Biophys Acta Date: 2008-06-14

9. Lysine 43 is trimethylated in subunit C from bovine mitochondrial ATP synthase and in storage bodies associated with batten disease.

Authors: Ruming Chen; Ian M Fearnley; David N Palmer; John E Walker
Journal: J Biol Chem Date: 2004-03-09 Impact factor: 5.157

Review 10. Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury.

Authors: Elizabeth Murphy; Charles Steenbergen
Journal: Physiol Rev Date: 2008-04 Impact factor: 37.312

20 in total

Review 1. Nitrite as a mediator of ischemic preconditioning and cytoprotection.

Authors: Daniel Murillo; Christelle Kamga; Li Mo; Sruti Shiva
Journal: Nitric Oxide Date: 2011-01-26 Impact factor: 4.427

2. Proteomic alterations of distinct mitochondrial subpopulations in the type 1 diabetic heart: contribution of protein import dysfunction.

Authors: Walter A Baseler; Erinne R Dabkowski; Courtney L Williamson; Tara L Croston; Dharendra Thapa; Matthew J Powell; Trust T Razunguzwa; John M Hollander
Journal: Am J Physiol Regul Integr Comp Physiol Date: 2010-11-03 Impact factor: 3.619

10. Loss of long-chain acyl-CoA synthetase isoform 1 impairs cardiac autophagy and mitochondrial structure through mechanistic target of rapamycin complex 1 activation.

Authors: Trisha J Grevengoed; Daniel E Cooper; Pamela A Young; Jessica M Ellis; Rosalind A Coleman
Journal: FASEB J Date: 2015-07-28 Impact factor: 5.191

Post-translational modifications of ATP synthase in the heart: biology and function.

1. Oxidative post-translational modification of tryptophan residues in cardiac mitochondrial proteins.

Review 2. Functions of site-specific histone acetylation and deacetylation.

3. Quantitative analysis of both protein expression and serine / threonine post-translational modifications through stable isotope labeling with dithiothreitol.

4. Proteome analysis reveals phosphorylation of ATP synthase beta -subunit in human skeletal muscle and proteins with potential roles in type 2 diabetes.

Review 5. Regulatory mechanisms of proton-translocating F(O)F (1)-ATP synthase.

6. Excessive ATP hydrolysis in ischemic myocardium by mitochondrial F1F0-ATPase: effect of selective pharmacological inhibition of mitochondrial ATPase hydrolase activity.

Review 7. Transport ATPases into the year 2008: a brief overview related to types, structures, functions and roles in health and disease.

Review 8. Chemical mechanisms of histone lysine and arginine modifications.

9. Lysine 43 is trimethylated in subunit C from bovine mitochondrial ATP synthase and in storage bodies associated with batten disease.

Review 10. Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury.

Review 1. Nitrite as a mediator of ischemic preconditioning and cytoprotection.

2. Proteomic alterations of distinct mitochondrial subpopulations in the type 1 diabetic heart: contribution of protein import dysfunction.

Review 3. Regulation of mitochondrial ATP synthase in cardiac pathophysiology.

Review 4. Role of mitochondrial Ca2+ in the regulation of cellular energetics.

Review 5. Proteomic responses of skeletal and cardiac muscle to exercise.

Review 6. Mitochondria from anoxia-tolerant animals reveal common strategies to survive without oxygen.

Review 7. OXPHOS mutations and neurodegeneration.

Review 8. Cysteine oxidative posttranslational modifications: emerging regulation in the cardiovascular system.

Review 9. Redox regulation of mitochondrial ATP synthase.

10. Loss of long-chain acyl-CoA synthetase isoform 1 impairs cardiac autophagy and mitochondrial structure through mechanistic target of rapamycin complex 1 activation.