Literature DB >> 19399034

Of flaky tails and itchy skin.

Donata Vercelli.   

Abstract

A new study defines the flaky tail mouse as a model for human atopic dermatitis caused by a null mutation in the gene encoding filaggrin, a key component of the epidermal barrier. Research in these mice will help explain how a disrupted barrier contributes to the pathogenesis of atopic dermatitis and to asthma arising in the context of atopic skin disease.

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Year:  2009        PMID： 19399034     DOI： 10.1038/ng0509-512

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  15 in total

1.  Skin barrier function and allergic risk.

Authors:  Thomas J Hudson
Journal:  Nat Genet       Date:  2006-04       Impact factor: 38.330

2.  Two new mutations in linkage group XVI of the house mouse. Flaky tail and varitint-waddler-J.

Authors:  P W Lane
Journal:  J Hered       Date:  1972 May-Jun       Impact factor: 2.645

Review 3.  Atopic dermatitis.

Authors:  Donald Y M Leung; Thomas Bieber
Journal:  Lancet       Date:  2003-01-11       Impact factor: 79.321

Review 4.  Eczema genetics: current state of knowledge and future goals.

Authors:  Sara J Brown; W H Irwin McLean
Journal:  J Invest Dermatol       Date:  2009-03       Impact factor: 8.551

Review 5.  Filaggrin in atopic dermatitis.

Authors:  Grainne M O'Regan; Aileen Sandilands; W H Irwin McLean; Alan D Irvine
Journal:  J Allergy Clin Immunol       Date:  2008-09-05       Impact factor: 10.793

6.  The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort study.

Authors:  John Henderson; Kate Northstone; Simon P Lee; Haihui Liao; Yiwei Zhao; Marcus Pembrey; Somnath Mukhopadhyay; George Davey Smith; Colin N A Palmer; W H Irwin McLean; Alan D Irvine
Journal:  J Allergy Clin Immunol       Date:  2008-03-05       Impact factor: 10.793

7.  A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming.

Authors:  Padraic G Fallon; Takashi Sasaki; Aileen Sandilands; Linda E Campbell; Sean P Saunders; Niamh E Mangan; John J Callanan; Hiroshi Kawasaki; Aiko Shiohama; Akiharu Kubo; John P Sundberg; Richard B Presland; Philip Fleckman; Nobuyoshi Shimizu; Jun Kudoh; Alan D Irvine; Masayuki Amagai; W H Irwin McLean
Journal:  Nat Genet       Date:  2009-04-06       Impact factor: 38.330

8.  Cytokine modulation of atopic dermatitis filaggrin skin expression.

Authors:  Michael D Howell; Byung Eui Kim; Peisong Gao; Audrey V Grant; Mark Boguniewicz; Anna Debenedetto; Lynda Schneider; Lisa A Beck; Kathleen C Barnes; Donald Y M Leung
Journal:  J Allergy Clin Immunol       Date:  2007-05-23       Impact factor: 10.793

9.  Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris.

Authors:  Frances J D Smith; Alan D Irvine; Ana Terron-Kwiatkowski; Aileen Sandilands; Linda E Campbell; Yiwei Zhao; Haihui Liao; Alan T Evans; David R Goudie; Sue Lewis-Jones; Gehan Arseculeratne; Colin S Munro; Ann Sergeant; Gráinne O'Regan; Sherri J Bale; John G Compton; John J DiGiovanna; Richard B Presland; Philip Fleckman; W H Irwin McLean
Journal:  Nat Genet       Date:  2006-01-29       Impact factor: 38.330

10.  Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure.

Authors:  Hans Bisgaard; Angela Simpson; Colin N A Palmer; Klaus Bønnelykke; Irwin McLean; Somnath Mukhopadhyay; Christian B Pipper; Liselotte B Halkjaer; Brian Lipworth; Jenny Hankinson; Ashley Woodcock; Adnan Custovic
Journal:  PLoS Med       Date:  2008-06-24       Impact factor: 11.069
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  3 in total

Review 1.  Allergic asthma: influence of genetic and environmental factors.

Authors:  Anil B Mukherjee; Zhongjian Zhang
Journal:  J Biol Chem       Date:  2011-07-28       Impact factor: 5.157

Review 2.  One remarkable molecule: filaggrin.

Authors:  Sara J Brown; W H Irwin McLean
Journal:  J Invest Dermatol       Date:  2011-12-08       Impact factor: 8.551

3.  Spontaneous atopic dermatitis-like symptoms in a/a ma ft/ma ft/J flaky tail mice appear early after birth.

Authors:  Magdalini Kypriotou; Cloé Boéchat; Marcel Huber; Daniel Hohl
Journal:  PLoS One       Date:  2013-07-03       Impact factor: 3.240
  3 in total

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