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Literature DB >> 19398951

Beclin 1: a BH3-only protein that fails to induce apoptosis.

Abstract

Beclin 1 has been recently shown to possess a Bcl-2 homology-3 (BH3) domain that mediates its interaction with antiapoptotic multidomain proteins. Unlike other BH3-only proteins, Beclin 1 fails to stimulate apoptosis when it is overexpressed. In this issue of Oncogene, Ciechomska et al. report the intriguing finding that Bcl-2, as it interacts with Beclin 1, does not lose its anti-apoptotic potential. This finding may have far-reaching implications for the comprehension of the cross-talk between apoptosis and autophagy.

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Year: 2009 PMID： 19398951 DOI： 10.1038/onc.2009.83

Source DB: PubMed Journal: Oncogene ISSN： 0950-9232 Impact factor: 9.867

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Cited

12 in total

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Authors: Yue Zhang; Stuart K Calderwood
Journal: Int J Hyperthermia Date: 2011 Impact factor: 3.914

2. Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy.

Authors: Flavie Strappazzon; Matteo Vietri-Rudan; Silvia Campello; Francesca Nazio; Fulvio Florenzano; Gian Maria Fimia; Mauro Piacentini; Beth Levine; Francesco Cecconi
Journal: EMBO J Date: 2011-02-25 Impact factor: 11.598

Review 3. Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress.

Authors: Shane Deegan; Svetlana Saveljeva; Adrienne M Gorman; Afshin Samali
Journal: Cell Mol Life Sci Date: 2012-09-28 Impact factor: 9.261

4. Cross-talk between apoptosis and autophagy in lung epithelial cell death.

Authors: Jincheng Yang; Hyung-Geun Moon; Sukrutha Chettimada; Yang Jin
Journal: J Biochem Pharmacol Res Date: 2014-04-05

5. Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis.

Authors: Ting-Kuang Niu; Yan Cheng; Xingcong Ren; Jin-Ming Yang
Journal: FEBS Lett Date: 2010-07-16 Impact factor: 4.124

6. Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria.

Authors: E Wirawan; L Vande Walle; K Kersse; S Cornelis; S Claerhout; I Vanoverberghe; R Roelandt; R De Rycke; J Verspurten; W Declercq; P Agostinis; T Vanden Berghe; S Lippens; P Vandenabeele
Journal: Cell Death Dis Date: 2010 Impact factor: 8.469

Beclin 1: a BH3-only protein that fails to induce apoptosis.

Review 1. Autophagy, protein aggregation and hyperthermia: a mini-review.

2. Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy.

Review 3. Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress.

4. Cross-talk between apoptosis and autophagy in lung epithelial cell death.

5. Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis.

6. Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria.

Review 7. Role of Cell Death in Cellular Processes During Odontogenesis.

8. Co-ordinated autophagy with resveratrol and γ-tocotrienol confers synergetic cardioprotection.

9. Roles of autophagy in androgen-induced benign prostatic hyperplasia in castrated rats.

10. Telomerase Reverse Transcriptase Contains a BH3-Like Motif and Interacts with BCL-2 Family Members.