Literature DB >> 19398558

Sgt1 dimerization is negatively regulated by protein kinase CK2-mediated phosphorylation at Ser361.

Parmil K Bansal1, Ashutosh Mishra, Anthony A High, Rashid Abdulle, Katsumi Kitagawa.   

Abstract

The kinetochore, which consists of centromere DNA and structural proteins, is essential for proper chromosome segregation in eukaryotes. In budding yeast, Sgt1 and Hsp90 are required for the binding of Skp1 to Ctf13 (a component of the core kinetochore complex CBF3) and therefore for the assembly of CBF3. We have previously shown that Sgt1 dimerization is important for this kinetochore assembly mechanism. In this study, we report that protein kinase CK2 phosphorylates Ser(361) on Sgt1, and this phosphorylation inhibits Sgt1 dimerization.

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Year:  2009        PMID： 19398558      PMCID： PMC2707205          DOI： 10.1074/jbc.M109.012732

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  48 in total

1.  Functional selection and analysis of yeast centromeric DNA.

Authors:  P Hieter; D Pridmore; J H Hegemann; M Thomas; R W Davis; P Philippsen
Journal:  Cell       Date:  1985-10       Impact factor: 41.582

2.  Type II regulatory subunit of cAMP-dependent protein kinase. Phosphorylation by casein kinase II at a site that is also phosphorylated in vivo.

Authors:  D F Carmichael; R L Geahlen; S M Allen; E G Krebs
Journal:  J Biol Chem       Date:  1982-09-10       Impact factor: 5.157

3.  Nucleotide sequence comparisons and functional analysis of yeast centromere DNAs.

Authors:  M Fitzgerald-Hayes; L Clarke; J Carbon
Journal:  Cell       Date:  1982-05       Impact factor: 41.582

4.  Mutational analysis of centromere DNA from chromosome VI of Saccharomyces cerevisiae.

Authors:  J H Hegemann; J H Shero; G Cottarel; P Philippsen; P Hieter
Journal:  Mol Cell Biol       Date:  1988-06       Impact factor: 4.272

5.  Yeast centromere binding protein CBF1, of the helix-loop-helix protein family, is required for chromosome stability and methionine prototrophy.

Authors:  M Cai; R W Davis
Journal:  Cell       Date:  1990-05-04       Impact factor: 41.582

6.  Purification of a yeast centromere-binding protein that is able to distinguish single base-pair mutations in its recognition site.

Authors:  M J Cai; R W Davis
Journal:  Mol Cell Biol       Date:  1989-06       Impact factor: 4.272

7.  Sgt1 is required for human kinetochore assembly.

Authors:  Peter Steensgaard; Massimiliano Garrè; Ivan Muradore; Pietro Transidico; Erich A Nigg; Katsumi Kitagawa; William C Earnshaw; Mario Faretta; Andrea Musacchio
Journal:  EMBO Rep       Date:  2004-05-07       Impact factor: 8.807

8.  Sgt1 associates with Hsp90: an initial step of assembly of the core kinetochore complex.

Authors:  Parmil K Bansal; Rashid Abdulle; Katsumi Kitagawa
Journal:  Mol Cell Biol       Date:  2004-09       Impact factor: 4.272

9.  Transformation of intact yeast cells treated with alkali cations.

Authors:  H Ito; Y Fukuda; K Murata; A Kimura
Journal:  J Bacteriol       Date:  1983-01       Impact factor: 3.490

10.  A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

Authors:  R S Sikorski; P Hieter
Journal:  Genetics       Date:  1989-05       Impact factor: 4.562
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  20 in total

1.  Alternative approaches to Hsp90 modulation for the treatment of cancer.

Authors:  Jessica A Hall; Leah K Forsberg; Brian S J Blagg
Journal:  Future Med Chem       Date:  2014-09       Impact factor: 3.808

2.  Sgt1 acts via an LKB1/AMPK pathway to establish cortical polarity in larval neuroblasts.

Authors:  Ryan O Andersen; Doug W Turnbull; Eric A Johnson; Chris Q Doe
Journal:  Dev Biol       Date:  2012-01-10       Impact factor: 3.582

3.  Dopamine D2 receptor signaling modulates mutant ataxin-1 S776 phosphorylation and aggregation.

Authors:  Scoty M Hearst; Mariper E Lopez; Qingmei Shao; Yong Liu; Parminder J S Vig
Journal:  J Neurochem       Date:  2010-04-30       Impact factor: 5.372

4.  Pepper suppressor of the G2 allele of skp1 interacts with the receptor-like cytoplasmic kinase1 and type III effector AvrBsT and promotes the hypersensitive cell death response in a phosphorylation-dependent manner.

Authors:  Nak Hyun Kim; Dae Sung Kim; Eui Hwan Chung; Byung Kook Hwang
Journal:  Plant Physiol       Date:  2014-03-31       Impact factor: 8.340

Review 5.  Cell-cycle phospho-regulation of the kinetochore.

Authors:  Cinzia Klemm; Peter H Thorpe; Guðjón Ólafsson
Journal:  Curr Genet       Date:  2020-11-22       Impact factor: 3.886

6.  Mutation of essential Hsp90 co-chaperones SGT1 or CNS1 renders yeast hypersensitive to overexpression of other co-chaperones.

Authors:  Jill L Johnson; Abbey D Zuehlke; Victoria R Tenge; Jordan C Langworthy
Journal:  Curr Genet       Date:  2014-06-13       Impact factor: 3.886

Review 7.  Post-translational modifications of Hsp90 and their contributions to chaperone regulation.

Authors:  Mehdi Mollapour; Len Neckers
Journal:  Biochim Biophys Acta       Date:  2011-08-10

8.  Identification of an Hsp90 mutation that selectively disrupts cAMP/PKA signaling in Saccharomyces cerevisiae.

Authors:  Gary A Flom; Ewa Langner; Jill L Johnson
Journal:  Curr Genet       Date:  2012-03-30       Impact factor: 3.886

9.  BUB3 that dissociates from BUB1 activates caspase-independent mitotic death (CIMD).

Authors:  Y Niikura; H Ogi; K Kikuchi; K Kitagawa
Journal:  Cell Death Differ       Date:  2010-01-08       Impact factor: 15.828

10.  Plk1 phosphorylates Sgt1 at the kinetochores to promote timely kinetochore-microtubule attachment.

Authors:  X Shawn Liu; Bing Song; Jiabin Tang; Weiyi Liu; Shihuan Kuang; Xiaoqi Liu
Journal:  Mol Cell Biol       Date:  2012-08-06       Impact factor: 4.272
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