| Literature DB >> 19398330 |
Alka Bali1, Sarika Malhotra, Himjyoti Dhir, Anil Kumar, Ajay Sharma.
Abstract
A series of 1-(quinoliloxypropyl)-4-aryl-piperazines has been synthesized and the target compounds evaluated for atypical antipsychotic activity in apomorphine induced mesh climbing and stereotypic behaviour in mice. The 8-hydroxyquinoline ether derivative 14 has emerged as an important lead compound showing a potential atypical antipsychotic profile. Employing appropriate physicochemical properties, the similarity of the compounds was assessed with respect to some atypical antipsychotic drugs as clozapine, ketanserine, ziprasidone and risperidone.Entities:
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Year: 2009 PMID： 19398330 DOI： 10.1016/j.bmcl.2009.04.019
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823