BACKGROUND: Methamphetamine, a derivative of amphetamine, has been well known to cause mental problems in humans; however, its physical effects are little known. Despite relevant information on the effect of methamphetamine abuse on bone quality being available, data regarding the frequency of osteoporosis in methamphetamine abusers are limited. METHODS: We selected 46 hospitalized male methamphetamine abusers and 188 reference male controls in whom any conditions affecting bone metabolism were ruled out. Bone mineral density (BMD) in the lumbar spine was measured by dual energy X-ray absorptiometry (DXA). We compared the BMD between methamphetamine abusers and controls and evaluated the frequency of osteoporosis in both groups. RESULTS: The mean BMD value was lower in methamphetamine abusers (mean+/-SD, 0.71+/-0.07 g/cm(2)) than in the controls (mean+/-SD, 0.98+/-0.14 g/cm(2)). The frequency of osteoporosis was 22% according to WHO diagnostic guidelines, and osteopenia at the lumbar spine was 76%. The correlation between the extent of methamphetamine abuse and BMD was very clear. CONCLUSION: There was considerable loss of bone mineral in a high percentage of methamphetamine abusers. Our study is the first clinical study to determine the frequency of osteoporosis in male methamphetamine abusers.
BACKGROUND:Methamphetamine, a derivative of amphetamine, has been well known to cause mental problems in humans; however, its physical effects are little known. Despite relevant information on the effect of methamphetamine abuse on bone quality being available, data regarding the frequency of osteoporosis in methamphetamine abusers are limited. METHODS: We selected 46 hospitalized male methamphetamine abusers and 188 reference male controls in whom any conditions affecting bone metabolism were ruled out. Bone mineral density (BMD) in the lumbar spine was measured by dual energy X-ray absorptiometry (DXA). We compared the BMD between methamphetamine abusers and controls and evaluated the frequency of osteoporosis in both groups. RESULTS: The mean BMD value was lower in methamphetamine abusers (mean+/-SD, 0.71+/-0.07 g/cm(2)) than in the controls (mean+/-SD, 0.98+/-0.14 g/cm(2)). The frequency of osteoporosis was 22% according to WHO diagnostic guidelines, and osteopenia at the lumbar spine was 76%. The correlation between the extent of methamphetamine abuse and BMD was very clear. CONCLUSION: There was considerable loss of bone mineral in a high percentage of methamphetamine abusers. Our study is the first clinical study to determine the frequency of osteoporosis in male methamphetamine abusers.
Authors: M Nygård; M P Mosti; L Brose; G Flemmen; A K Stunes; A Sørskår-Venæs; J Heggelund; E Wang Journal: Osteoporos Int Date: 2018-07-05 Impact factor: 4.507
Authors: Albert Y Liu; Eric Vittinghoff; Deborah E Sellmeyer; Risha Irvin; Kathleen Mulligan; Kenneth Mayer; Melanie Thompson; Robert Grant; Sonal Pathak; Brandon O'Hara; Roman Gvetadze; Kata Chillag; Lisa Grohskopf; Susan P Buchbinder Journal: PLoS One Date: 2011-08-29 Impact factor: 3.240
Authors: Byung Dae Lee; Je Min Park; Young Min Lee; Eun Soo Moon; Hee Jeong Jeong; Young In Chung; Hyo Deog Rim Journal: Clin Psychopharmacol Neurosci Date: 2014-04-24 Impact factor: 2.582