J H Cho1, C K Cho, J W Shin, J Y Son, W Kang, C G Son. 1. East-West Cancer Center, Dunsan Oriental Hospital of Oriental Medical College of Daejeon University, Seo-gu, Daejeon, South Korea.
Abstract
OBJECTIVES: To investigate the anti-fatigue effects of Myelophil, an extract of a mix of Astragali Radix and Salviae Radix, which has been used to treat patients with chronic fatigue. SUBJECTS AND DESIGN: A randomised, double-blind, controlled clinical trial was performed with 36 adults who complained of chronic fatigue. The subjects were divided among a control group and low- and high-dose groups (3 or 6g of oral Myelophil per day, respectively) and were monitored for 4 weeks. Fatigue severity was subjectively characterised, and the expression of 42 cytokines was evaluated using an antibody array. RESULTS:Myelophil administration (3g per day) significantly decreased the fatigue severity score compared with the control (p<0.05). No changes were noted in cytokine expression. CONCLUSIONS:Myelophil appears to have a pharmacological effect against fatigue, suggesting the clinical relevance of the traditional medicinal plants, Astragalus membranaceus and Salvia miltiorrhiza.
RCT Entities:
OBJECTIVES: To investigate the anti-fatigue effects of Myelophil, an extract of a mix of Astragali Radix and Salviae Radix, which has been used to treat patients with chronic fatigue. SUBJECTS AND DESIGN: A randomised, double-blind, controlled clinical trial was performed with 36 adults who complained of chronic fatigue. The subjects were divided among a control group and low- and high-dose groups (3 or 6g of oral Myelophil per day, respectively) and were monitored for 4 weeks. Fatigue severity was subjectively characterised, and the expression of 42 cytokines was evaluated using an antibody array. RESULTS: Myelophil administration (3g per day) significantly decreased the fatigue severity score compared with the control (p<0.05). No changes were noted in cytokine expression. CONCLUSIONS: Myelophil appears to have a pharmacological effect against fatigue, suggesting the clinical relevance of the traditional medicinal plants, Astragalus membranaceus and Salvia miltiorrhiza.
Authors: Katrin M Hoffmann; Robin Herbrechter; Paul M Ziemba; Peter Lepke; Leopoldo Beltrán; Hanns Hatt; Markus Werner; Günter Gisselmann Journal: Front Pharmacol Date: 2016-07-29 Impact factor: 5.810