B V Ghule1, M H Ghante, A N Saoji, P G Yeole. 1. Institute of Pharmaceutical Education and Research, Department of Pharmacognosy and Phytochemistry, Borgaon (Meghe), Wardha, Maharashtra 442 001, India. ghulebv@rediffmail.com
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: Lagenaria siceraria Stand. (Cucurbitaceae) fruits have been used, traditionally, in the treatment of hyperlipidemia and atherosclerotic impasse and considered as cardioprotective and cardiotonic drug. AIM OF THE STUDY: The present work was undertaken to investigate the effects of methanolic extract from Lagenaria siceraria in experimentally induced hyperlipidemia in rats. MATERIALS AND METHODS: Methanolic extract of Lagenaria siceraria fruits (LSFE) (100, 200 and 300 mg/kg; p.o.) was administered to the high fat-diet-induced hyperlipidemic rats for 30 days to evaluate its antihyperlipidemic activity. Atorvastatin (10mg/kg; p.o.) was used as a standard drug. RESULTS: At the 30 th day, most significant reduction in lipid levels in the LSFE treated rats as compared to the rats fed with high-fat diet at the 0th day were: total cholesterol 290.14+/-18.42 mg/dl vs. 228.58+/-16.38 mg/dl, low-density lipoprotein cholesterol 195.14+/-8.86 mg/dl vs. 120.57+/-8.11 mg/dl, triglyceride 232.41+/-15.22 mg/dl vs. 181.79+/-15.68 mg/dl, very low-density lipoprotein cholesterol 46.48+/-3.04 mg/dl vs. 36.35+/-3.13 mg/dl (P<0.0001). Conversely, high-density lipoprotein cholesterol levels were significantly (P<0.0001) increased from 48.52+/-6.52 to 71.66+/-5.14 mg/dl. The increase in weight in rats administered with LSFE was less when compared to rats fed with high-fat diet. Moreover, LSFE also exhibited significant increase in excretion of bile acids. CONCLUSION: The results demonstrate that the LSFE has a definite antihyperlipidemic potential. There is also a valid scientific basis for consuming it in the treatment of coronary artery diseases in India.
ETHNOPHARMACOLOGICAL RELEVANCE: Lagenaria siceraria Stand. (Cucurbitaceae) fruits have been used, traditionally, in the treatment of hyperlipidemia and atherosclerotic impasse and considered as cardioprotective and cardiotonic drug. AIM OF THE STUDY: The present work was undertaken to investigate the effects of methanolic extract from Lagenaria siceraria in experimentally induced hyperlipidemia in rats. MATERIALS AND METHODS:Methanolic extract of Lagenaria siceraria fruits (LSFE) (100, 200 and 300 mg/kg; p.o.) was administered to the high fat-diet-induced hyperlipidemic rats for 30 days to evaluate its antihyperlipidemic activity. Atorvastatin (10mg/kg; p.o.) was used as a standard drug. RESULTS: At the 30 th day, most significant reduction in lipid levels in the LSFE treated rats as compared to the rats fed with high-fat diet at the 0th day were: total cholesterol 290.14+/-18.42 mg/dl vs. 228.58+/-16.38 mg/dl, low-density lipoprotein cholesterol 195.14+/-8.86 mg/dl vs. 120.57+/-8.11 mg/dl, triglyceride 232.41+/-15.22 mg/dl vs. 181.79+/-15.68 mg/dl, very low-density lipoprotein cholesterol 46.48+/-3.04 mg/dl vs. 36.35+/-3.13 mg/dl (P<0.0001). Conversely, high-density lipoprotein cholesterol levels were significantly (P<0.0001) increased from 48.52+/-6.52 to 71.66+/-5.14 mg/dl. The increase in weight in rats administered with LSFE was less when compared to rats fed with high-fat diet. Moreover, LSFE also exhibited significant increase in excretion of bile acids. CONCLUSION: The results demonstrate that the LSFE has a definite antihyperlipidemic potential. There is also a valid scientific basis for consuming it in the treatment of coronary artery diseases in India.
Authors: Muhammad Saeed; Muhammad Sajjad Khan; Kinza Amir; Jannat Bi Bi; Muhammad Asif; Asadullah Madni; Asghar Ali Kamboh; Zahid Manzoor; Umair Younas; Sun Chao Journal: Front Nutr Date: 2022-09-16