Literature DB >> 19397475

ADAM8: a new therapeutic target for asthma.

Martin D Knolle1, Caroline A Owen.   

Abstract

BACKGROUND: A proteinase with a disintegrin and a metalloproteinase domain-8 (ADAM8) has been linked to asthma.
OBJECTIVE: To explore whether ADAM8 is a therapeutic target for asthma.
METHODS: We reviewed literature on ADAM8's function and expression and activities in lungs of humans and mice with allergic airway inflammation (AAI). We used these data to generate hypotheses about the contributions of ADAM8 to asthma pathogenesis.
CONCLUSIONS: ADAM8 levels are increased in airway epithelium and airway inflammatory cells in mice with AAI and human asthma patients. Data from murine models of AAI indicate that ADAM8 dampens airway inflammation. It is not clear whether ADAM8 contributes directly to structural remodeling in asthmatic airways. Additional studies are required to validate ADAM8 as a therapeutic target for asthma.

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Year:  2009        PMID： 19397475      PMCID： PMC2784995          DOI： 10.1517/14728220902889788

Source DB:  PubMed          Journal:  Expert Opin Ther Targets        ISSN： 1472-8222            Impact factor:   6.902


  145 in total

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Journal:  Am J Respir Crit Care Med       Date:  2001-08-01       Impact factor: 21.405

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