Literature DB >> 19396850

Non-hydrolyzable RNA-peptide conjugates: a powerful advance in the synthesis of mimics for 3'-peptidyl tRNA termini.

Holger Moroder1, Jessica Steger, Dagmar Graber, Katja Fauster, Krista Trappl, Viter Marquez, Norbert Polacek, Daniel N Wilson, Ronald Micura.   

Abstract

Translation of specific small peptides on the ribosome can confer resistance to macrolide antibiotics. To reveal the molecular details of this and related phenomena, stable RNA-peptide conjugates that mimic peptidyl-tRNA would be desirable, especially for ribosome structural biology. A flexible solid-phase synthesis strategy now allows efficient access to these highly requested derivatives without restriction on the RNA and peptide sequences.

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Year:  2009        PMID： 19396850     DOI： 10.1002/anie.200900939

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  14 in total

1.  Preparation of modified long-mer RNAs and analysis of FMN binding to the ypaA aptamer from B. subtilis.

Authors:  Jennifer Frommer; Robert Hieronymus; Tamil Selvi Arunachalam; Sabine Heeren; Maria Jenckel; Anne Strahl; Bettina Appel; Sabine Müller
Journal:  RNA Biol       Date:  2014-03-26       Impact factor: 4.652

2.  Synthesis of peptide-oligonucleotide conjugates using a heterobifunctional crosslinker.

Authors:  Berea A R Williams; John C Chaput
Journal:  Curr Protoc Nucleic Acid Chem       Date:  2010-09

3.  Reliable semi-synthesis of hydrolysis-resistant 3'-peptidyl-tRNA conjugates containing genuine tRNA modifications.

Authors:  Dagmar Graber; Holger Moroder; Jessica Steger; Krista Trappl; Norbert Polacek; Ronald Micura
Journal:  Nucleic Acids Res       Date:  2010-06-04       Impact factor: 16.971

4.  Conformational and chemical selection by a trans-acting editing domain.

Authors:  Eric M Danhart; Marina Bakhtina; William A Cantara; Alexandra B Kuzmishin; Xiao Ma; Brianne L Sanford; Oscar Vargas-Rodriguez; Marija Košutić; Yuki Goto; Hiroaki Suga; Kotaro Nakanishi; Ronald Micura; Mark P Foster; Karin Musier-Forsyth
Journal:  Proc Natl Acad Sci U S A       Date:  2017-08-02       Impact factor: 11.205

5.  Molecular insights into protein synthesis with proline residues.

Authors:  Sergey Melnikov; Justine Mailliot; Lukas Rigger; Sandro Neuner; Byung-Sik Shin; Gulnara Yusupova; Thomas E Dever; Ronald Micura; Marat Yusupov
Journal:  EMBO Rep       Date:  2016-11-08       Impact factor: 8.807

6.  The synthesis of methylated, phosphorylated, and phosphonated 3'-aminoacyl-tRNA(Sec) mimics.

Authors:  Lukas Rigger; Rachel L Schmidt; Kaitlyn M Holman; Miljan Simonović; Ronald Micura
Journal:  Chemistry       Date:  2013-10-14       Impact factor: 5.236

7.  Binding of Macrolide Antibiotics Leads to Ribosomal Selection against Specific Substrates Based on Their Charge and Size.

Authors:  Shanmugapriya Sothiselvam; Sandro Neuner; Lukas Rigger; Dorota Klepacki; Ronald Micura; Nora Vázquez-Laslop; Alexander S Mankin
Journal:  Cell Rep       Date:  2016-08-04       Impact factor: 9.423

8.  Selective desulfurization significantly expands sequence variety of 3'-peptidyl-tRNA mimics obtained by native chemical ligation.

Authors:  Anna-Skrollan Geiermann; Ronald Micura
Journal:  Chembiochem       Date:  2012-07-11       Impact factor: 3.164

9.  Functionalized polystyrene supports for solid-phase synthesis of glycyl-, alanyl-, and isoleucyl-RNA conjugates as hydrolysis-resistant mimics of peptidyl-tRNAs.

Authors:  Jessica Steger; Ronald Micura
Journal:  Bioorg Med Chem       Date:  2011-07-19       Impact factor: 3.641

10.  Small molecule binding, docking, and characterization of the interaction between Pth1 and peptidyl-tRNA.

Authors:  Mary C Hames; Hana McFeeters; W Blake Holloway; Christopher B Stanley; Volker S Urban; Robert L McFeeters
Journal:  Int J Mol Sci       Date:  2013-11-19       Impact factor: 5.923
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