BACKGROUND: The efficacy and safety of novel topical inhibitors of corneal neovascularisation will be discussed. METHODS: A literature review after a PUBMED search and own clinical and experimental results are presented. RESULTS: The off-label use of Avastin eye drops and GS101 eye drops against insulin receptor substrate (IRS)-1, which have been tested in phase II trial, both seem to be relatively efficient and safe ways to inhibit progressive corneal neovascularisation. Other VEGF antagonists, such as ranibizumab and pegaptanib eye drops also inhibit corneal neovascularisation. CONCLUSIONS: Avastin and GS101 eye drops are the first specific angiogenesis inhibitors for topical inhibition of corneal angiogenesis available for clinical use.
BACKGROUND: The efficacy and safety of novel topical inhibitors of corneal neovascularisation will be discussed. METHODS: A literature review after a PUBMED search and own clinical and experimental results are presented. RESULTS: The off-label use of Avastin eye drops and GS101 eye drops against insulin receptor substrate (IRS)-1, which have been tested in phase II trial, both seem to be relatively efficient and safe ways to inhibit progressive corneal neovascularisation. Other VEGF antagonists, such as ranibizumab and pegaptanib eye drops also inhibit corneal neovascularisation. CONCLUSIONS:Avastin and GS101 eye drops are the first specific angiogenesis inhibitors for topical inhibition of corneal angiogenesis available for clinical use.
Authors: C Cursiefen; H Wenkel; P Martus; A Langenbucher; N X Nguyen; B Seitz; M Küchle; G O Naumann Journal: Graefes Arch Clin Exp Ophthalmol Date: 2001-07 Impact factor: 3.117
Authors: Tina Dietrich; Jasmine Onderka; Felix Bock; Friedrich E Kruse; Dörte Vossmeyer; Roland Stragies; Grit Zahn; Claus Cursiefen Journal: Am J Pathol Date: 2007-07 Impact factor: 4.307
Authors: Efdal Yoeruek; Martin S Spitzer; Olcay Tatar; Sabine Aisenbrey; Karl U Bartz-Schmidt; Peter Szurman Journal: Cornea Date: 2007-09 Impact factor: 2.651
Authors: Anna Énzsöly; Katalin Markó; Tamás Tábi; Éva Szökő; Romána Zelkó; Miklós Tóth; J Mark Petrash; Péter Mátyus; János Németh Journal: J Neural Transm (Vienna) Date: 2013-02-09 Impact factor: 3.575