Literature DB >> 19395872

Rapamycin inhibits mTORC1, but not completely.

Carson C Thoreen1, David M Sabatini.   

Abstract

Rapamycin is widely used as a complete inhibitor of the mTORC1 nutrient-sensitive signaling complex. Using a novel ATP-competitive inhibitor named Torin1, we have found that many mTORC1 functions that regulate cap-dependent translation and autophagy are resistant to inhibition by rapamycin.

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Year:  2009        PMID： 19395872     DOI： 10.4161/auto.5.5.8504

Source DB:  PubMed          Journal:  Autophagy        ISSN： 1554-8627            Impact factor:   16.016


  127 in total

1.  Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses.

Authors:  Fabien P Blanchet; Arnaud Moris; Damjan S Nikolic; Martin Lehmann; Sylvain Cardinaud; Romaine Stalder; Eduardo Garcia; Christina Dinkins; Florence Leuba; Li Wu; Olivier Schwartz; Vojo Deretic; Vincent Piguet
Journal:  Immunity       Date:  2010-05-06       Impact factor: 31.745

2.  Non-small cell lung carcinoma therapy using mTOR-siRNA.

Authors:  Hirochika Matsubara; Kenji Sakakibara; Tamo Kunimitsu; Hiroyasu Matsuoka; Kaori Kato; Noboru Oyachi; Yoh Dobashi; Masahiko Matsumoto
Journal:  Int J Clin Exp Pathol       Date:  2012-02-12

3.  S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response.

Authors:  Keng Po Lai; Wai Fook Leong; Jenny Fung Ling Chau; Deyong Jia; Li Zeng; Huijuan Liu; Lin He; Aijun Hao; Hongbing Zhang; David Meek; Chakradhar Velagapudi; Samy L Habib; Baojie Li
Journal:  EMBO J       Date:  2010-07-23       Impact factor: 11.598

4.  Characterizing Cellular Biophysical Responses to Stress by Relating Density, Deformability, and Size.

Authors:  Sangwon Byun; Vivian C Hecht; Scott R Manalis
Journal:  Biophys J       Date:  2015-10-20       Impact factor: 4.033

5.  Lysosome Positioning Influences mTORC2 and AKT Signaling.

Authors:  Rui Jia; Juan S Bonifacino
Journal:  Mol Cell       Date:  2019-05-23       Impact factor: 17.970

Review 6.  Autophagy and cancer cell metabolism.

Authors:  Fred Lozy; Vassiliki Karantza
Journal:  Semin Cell Dev Biol       Date:  2012-01-18       Impact factor: 7.727

7.  Targeting of mTORC2 may have advantages over selective targeting of mTORC1 in the treatment of malignant pheochromocytoma.

Authors:  Xiaohua Zhang; Xianjin Wang; Tianyuan Xu; Shan Zhong; Zhoujun Shen
Journal:  Tumour Biol       Date:  2015-02-11

8.  Continuous administration of the mTORC1 inhibitor everolimus induces tolerance and decreases autophagy in mice.

Authors:  Ammar Kurdi; Mireille De Doncker; Arthur Leloup; Hugo Neels; Jean-Pierre Timmermans; Katrien Lemmens; Sandra Apers; Guido R Y De Meyer; Wim Martinet
Journal:  Br J Pharmacol       Date:  2016-10-23       Impact factor: 8.739

9.  Interaction of mTOR and Erk1/2 signaling to regulate oligodendrocyte differentiation.

Authors:  JinXiang Dai; Kathryn K Bercury; Wendy B Macklin
Journal:  Glia       Date:  2014-07-25       Impact factor: 7.452

10.  Mammalian target of rapamycin complex 1 (mTORC1) plays a role in Pasteurella multocida toxin (PMT)-induced protein synthesis and proliferation in Swiss 3T3 cells.

Authors:  Hammou Oubrahim; Allison Wong; Brenda A Wilson; P Boon Chock
Journal:  J Biol Chem       Date:  2012-12-07       Impact factor: 5.157
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