Literature DB >> 19395863

Pharmacological inhibition of aurora-A but not aurora-B impairs interphase microtubule dynamics.

Corinne Lorenzo1, Qiaoyin Liao, Mary Ann Hardwicke, Bernard Ducommun.   

Abstract

Aurora kinases are key cell cycle regulators and represent attractive new targets in cancer therapy. In this work we investigated the effect of specific inhibition of Aurora-A and Aurora-B on interphase microtubule dynamics using the GSK6000063A and AZD1152 HQPA compounds respectively. We show that Aurora-A inhibition results in microtubule network disorganization and bundling. Using video microscopy and laser-based photo ablation we demonstrate that Aurora-A inhibition decreases microtubule shrinkage, growth rate, frequency rescue and nucleation. These results open new perspectives on the role of Aurora-A in interphase and might be worth considering in a pharmacological perspective.

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Year:  2009        PMID： 19395863     DOI： 10.4161/cc.8.11.8617

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  13 in total

Review 1.  The Unexpected Roles of Aurora A Kinase in Gliobastoma Recurrences.

Authors:  Estelle Willems; Arnaud Lombard; Matthias Dedobbeleer; Nicolas Goffart; Bernard Rogister
Journal:  Target Oncol       Date:  2017-02       Impact factor: 4.493

Review 2.  Aurora A kinase (AURKA) in normal and pathological cell division.

Authors:  Anna S Nikonova; Igor Astsaturov; Ilya G Serebriiskii; Roland L Dunbrack; Erica A Golemis
Journal:  Cell Mol Life Sci       Date:  2012-08-03       Impact factor: 9.261

3.  Rapid calcium-dependent activation of Aurora-A kinase.

Authors:  Olga V Plotnikova; Elena N Pugacheva; Roland L Dunbrack; Erica A Golemis
Journal:  Nat Commun       Date:  2010-09-07       Impact factor: 14.919

4.  Calmodulin activation of Aurora-A kinase (AURKA) is required during ciliary disassembly and in mitosis.

Authors:  Olga V Plotnikova; Anna S Nikonova; Yuri V Loskutov; Polina Y Kozyulina; Elena N Pugacheva; Erica A Golemis
Journal:  Mol Biol Cell       Date:  2012-05-23       Impact factor: 4.138

5.  Combining the pan-aurora kinase inhibitor AMG 900 with histone deacetylase inhibitors enhances antitumor activity in prostate cancer.

Authors:  Channing J Paller; Michel D Wissing; Janet Mendonca; Anup Sharma; Eugene Kim; Hea-Soo Kim; Madeleine S Q Kortenhorst; Stephanie Gerber; Marc Rosen; Faraz Shaikh; Marianna L Zahurak; Michelle A Rudek; Hans Hammers; Charles M Rudin; Michael A Carducci; Sushant K Kachhap
Journal:  Cancer Med       Date:  2014-07-03       Impact factor: 4.452

6.  Aurora A kinase phosphorylates Hec1 to regulate metaphase kinetochore-microtubule dynamics.

Authors:  Keith F DeLuca; Amanda Meppelink; Amanda J Broad; Jeanne E Mick; Olve B Peersen; Sibel Pektas; Susanne M A Lens; Jennifer G DeLuca
Journal:  J Cell Biol       Date:  2017-11-29       Impact factor: 10.539

Review 7.  LIM kinases: cofilin and beyond.

Authors:  Chloé Prunier; Renaud Prudent; Reuben Kapur; Karin Sadoul; Laurence Lafanechère
Journal:  Oncotarget       Date:  2017-06-20

8.  A New Quantitative Cell-Based Assay Reveals Unexpected Microtubule Stabilizing Activity of Certain Kinase Inhibitors, Clinically Approved or in the Process of Approval.

Authors:  Sacnicte Ramirez-Rios; Sophie Michallet; Leticia Peris; Caroline Barette; Clotilde Rabat; Yangbo Feng; Marie-Odile Fauvarque; Annie Andrieux; Karin Sadoul; Laurence Lafanechère
Journal:  Front Pharmacol       Date:  2020-04-30       Impact factor: 5.810

9.  Tripolin A, a novel small-molecule inhibitor of aurora A kinase, reveals new regulation of HURP's distribution on microtubules.

Authors:  Iliana A Kesisova; Konstantinos C Nakos; Avgi Tsolou; Dimitrios Angelis; Joe Lewis; Aikaterini Chatzaki; Bogos Agianian; Athanassios Giannis; Maria D Koffa
Journal:  PLoS One       Date:  2013-03-13       Impact factor: 3.240

10.  Rac1 and Aurora A regulate MCAK to polarize microtubule growth in migrating endothelial cells.

Authors:  Alexander Braun; Kyvan Dang; Felinah Buslig; Michelle A Baird; Michael W Davidson; Clare M Waterman; Kenneth A Myers
Journal:  J Cell Biol       Date:  2014-07-07       Impact factor: 10.539
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