| Literature DB >> 19395263 |
Hugues Massimba Dibama1, Igor Clarot, Stéphane Fontanay, Adel Ben Salem, Maxime Mourer, Chantal Finance, Raphaël E Duval, Jean-Bernard Regnouf-de-Vains.
Abstract
A water-soluble calixarene-based heterocyclic podand incorporating a quinolone antibiotic subunit, the nalidixic acid, was synthesised and fully characterised. Its prodrug behaviour was assessed in vitro by HPLC, demonstrating the release of the tethered quinolone in model biological conditions. Microbiological studies performed on various Gram-positive and Gram-negative reference strains showed very interesting antibacterial activities.Entities:
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Year: 2009 PMID： 19395263 DOI： 10.1016/j.bmcl.2009.03.139
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823