PURPOSE: Limited data suggest that alcohol drinking may have an inverse relation to risk of non-Hodgkin's lymphoma (NHL). Prospective data about alcohol, NHL, and other hematologic malignancies (HM) are sparse. METHODS: We carried out a cohort study in a multiethnic population of 126,293 adults who supplied baseline information at health examinations. There were subsequent HM diagnoses in 1244 persons. We used Cox proportional hazards models with seven covariates. The role of beverage types was studied by comparing groups with preponderant choices and by studying the role of frequency of drinking beverage types. RESULTS: Using lifelong abstainers plus infrequent drinkers as referent, adjusted relative risks (95% confidence intervals) for HM follow: less than one drink per day=1.0 (0.9-1.2), one to two drinks per day=0.9 (0.7-1.0), greater than three drinks per day=0.7 (0.6-0.9, p=0.008). For 673 NHL these were 1.2 (1.0-1.5), 0.9 (0.7-1.2), and 0.9 (0.6-1.2). Persons reporting greater than three drinks/day had inverse relations to lymphocytic (n= 146) and myelocytic (n= 169) leukemias, with relative risk of 0.5 (0.2-1.0, p<0.05) for each. No major independent relation was seen for choice of wine, liquor, or beer. CONCLUSIONS: Alcohol drinking is associated with slightly lower risk of HM, due largely to inverse relations to lymphocytic and myelocytic leukemia.
PURPOSE: Limited data suggest that alcohol drinking may have an inverse relation to risk of non-Hodgkin's lymphoma (NHL). Prospective data about alcohol, NHL, and other hematologic malignancies (HM) are sparse. METHODS: We carried out a cohort study in a multiethnic population of 126,293 adults who supplied baseline information at health examinations. There were subsequent HM diagnoses in 1244 persons. We used Cox proportional hazards models with seven covariates. The role of beverage types was studied by comparing groups with preponderant choices and by studying the role of frequency of drinking beverage types. RESULTS: Using lifelong abstainers plus infrequent drinkers as referent, adjusted relative risks (95% confidence intervals) for HM follow: less than one drink per day=1.0 (0.9-1.2), one to two drinks per day=0.9 (0.7-1.0), greater than three drinks per day=0.7 (0.6-0.9, p=0.008). For 673 NHL these were 1.2 (1.0-1.5), 0.9 (0.7-1.2), and 0.9 (0.6-1.2). Persons reporting greater than three drinks/day had inverse relations to lymphocytic (n= 146) and myelocytic (n= 169) leukemias, with relative risk of 0.5 (0.2-1.0, p<0.05) for each. No major independent relation was seen for choice of wine, liquor, or beer. CONCLUSIONS:Alcohol drinking is associated with slightly lower risk of HM, due largely to inverse relations to lymphocytic and myelocytic leukemia.
Authors: Gabriella Andreotti; Brenda Birmann; Anneclaire J De Roos; John Spinelli; Wendy Cozen; Nicola J Camp; Kirsten Moysich; Brian Chiu; Emily Steplowski; Joseph Krzystan; Paolo Boffetta; Véronique Benhaim-Luzon; Paul Brennan; Silvia de Sanjosé; Laura Costas; Adele Seniori Costantini; Lucia Miligi; Pierluigi Cocco; Nikolaus Becker; Lenka Foretová; Marc Maynadié; Alexandra Nieters; Anthony Staines; Guido Tricot; Kevin Milliken; Dennis Weisenburger; Tongzhang Zheng; Dalsu Baris; Mark P Purdue Journal: Cancer Epidemiol Biomarkers Prev Date: 2013-08-20 Impact factor: 4.254