| Literature DB >> 19394829 |
Peter Kutschy1, Aneta Salayová, Zuzana Curillová, Tibor Kozár, Roman Mezencev, Ján Mojzis, Martina Pilátová, Eva Balentová, Pavel Pazdera, Marián Sabol, Michaela Zburová.
Abstract
New analogs of indole phytoalexin 1-methoxyspirobrassinol methyl ether have been designed by replacement of its 2-methoxy group with 2-(substituted phenyl)amino group. Synthesized by spirocyclization methodology, trans- and cis-diastereoisomers of target compounds were isolated and evaluated as potential anticancer and antimicrobial agents. Their molecular geometries were refined by ab initio minimizations. Pharmacophore modeling and QSAR studies were performed in order to correlate their molecular structure and biological activity.Entities:
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Year: 2009 PMID： 19394829 DOI： 10.1016/j.bmc.2009.03.064
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641