Literature DB >> 19394822

Inhibition of Pseudomonas aeruginosa quorum sensing by AI-2 analogs.

Hadas Ganin1, Xu Tang, Michael M Meijler.   

Abstract

Autoinducer-2 (AI-2) has been suggested to serve as a universal interspecies quorum sensing signaling molecule. We have synthesized a set of AI-2 analogs with small incremental changes in alkyl substitution on C-2 and evaluated them for their agonistic and antagonistic potential as quorum sensing (QS) attenuators in two different bacterial species: Pseudomonas aeruginosa and Vibrio harveyi. Unexpectedly, several of the analogs were found to function as synergistic QS agonists in V. harveyi, while two of these analogs inhibit QS in P. aeruginosa.

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Year:  2009        PMID： 19394822     DOI： 10.1016/j.bmcl.2009.03.163

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  17 in total

Review 1.  Quorum sensing and social networking in the microbial world.

Authors:  Steve Atkinson; Paul Williams
Journal:  J R Soc Interface       Date:  2009-08-12       Impact factor: 4.118

2.  Probing autoinducer-2 based quorum sensing: the biological consequences of molecules unable to traverse equilibrium states.

Authors:  Kyoji Tsuchikama; Colin A Lowery; Kim D Janda
Journal:  J Org Chem       Date:  2011-06-28       Impact factor: 4.354

Review 3.  Exploiting quorum sensing to confuse bacterial pathogens.

Authors:  Breah LaSarre; Michael J Federle
Journal:  Microbiol Mol Biol Rev       Date:  2013-03       Impact factor: 11.056

4.  Uncharacterized 4,5-dihydroxy-2,3-pentanedione (DPD) molecules revealed through NMR spectroscopy: implications for a greater signaling diversity in bacterial species.

Authors:  Daniel Globisch; Colin A Lowery; Karen C McCague; Kim D Janda
Journal:  Angew Chem Int Ed Engl       Date:  2012-02-29       Impact factor: 15.336

Review 5.  Silencing the mob: disrupting quorum sensing as a means to fight plant disease.

Authors:  Yael Helman; Leonid Chernin
Journal:  Mol Plant Pathol       Date:  2014-09-29       Impact factor: 5.663

6.  Novel reporter for identification of interference with acyl homoserine lactone and autoinducer-2 quorum sensing.

Authors:  Nancy Weiland-Bräuer; Nicole Pinnow; Ruth A Schmitz
Journal:  Appl Environ Microbiol       Date:  2015-02       Impact factor: 4.792

7.  Crystal structures of the LsrR proteins complexed with phospho-AI-2 and two signal-interrupting analogues reveal distinct mechanisms for ligand recognition.

Authors:  Jung-Hye Ha; Yumi Eo; Alexander Grishaev; Min Guo; Jacqueline A I Smith; Herman O Sintim; Eun-Hee Kim; Hae-Kap Cheong; William E Bentley; Kyoung-Seok Ryu
Journal:  J Am Chem Soc       Date:  2013-10-01       Impact factor: 15.419

8.  Mechanistic insights into the LsrK kinase required for autoinducer-2 quorum sensing activation.

Authors:  Jie Zhu; Mark S Hixon; Daniel Globisch; Gunnar F Kaufmann; Kim D Janda
Journal:  J Am Chem Soc       Date:  2013-05-16       Impact factor: 15.419

9.  Revisiting AI-2 quorum sensing inhibitors: direct comparison of alkyl-DPD analogues and a natural product fimbrolide.

Authors:  Colin A Lowery; Takumi Abe; Junguk Park; Lisa M Eubanks; Daisuke Sawada; Gunnar F Kaufmann; Kim D Janda
Journal:  J Am Chem Soc       Date:  2009-11-04       Impact factor: 15.419

10.  C4-alkoxy-HPD: a potent class of synthetic modulators surpassing nature in AI-2 quorum sensing.

Authors:  Kyoji Tsuchikama; Jie Zhu; Colin A Lowery; Gunnar F Kaufmann; Kim D Janda
Journal:  J Am Chem Soc       Date:  2012-08-09       Impact factor: 15.419
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