| Literature DB >> 19394799 |
Verna Louhivuori1, Maria Arvio, Pia Soronen, Virpi Oksanen, Tiina Paunio, Maija L Castrén.
Abstract
The Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene may modulate the epilepsy phenotype. We investigated the impact of polymorphisms in the BDNF gene on clinical features in fragile X syndrome (FXS). In our study sample, the Met66 allele associated with epilepsy of finnish FXS men. Abnormalities in BDNF-mediated plasticity are shown in FXS and the present data suggest that the Met66 allele might predispose FXS males to epilepsy.Entities:
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Year: 2009 PMID： 19394799 DOI： 10.1016/j.eplepsyres.2009.01.005
Source DB: PubMed Journal: Epilepsy Res ISSN： 0920-1211 Impact factor: 3.045