| Literature DB >> 19394719 |
Miguel Fernández Braña1, Nuria Acero, Loreto Añorbe, Dolores Muñoz Mingarro, Francisco Llinares, Gema Domínguez.
Abstract
A new series of imide derivatives related to thalidomide were synthesized and evaluated as modulators of TNF-alpha production. These derivatives enhance TNF-alpha production using human leukemia HL-60 cells induced with 12-O-tetradecanoylphorbol 13-acetate (TPA), while inhibiting TNF-alpha production induced with okadaic acid (OA) in the same cell line. The diphenylmaleimide derivative 2f, was found to be the most active product, producing a strong modulation of the cytokine level.Entities:
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Year: 2009 PMID： 19394719 DOI： 10.1016/j.ejmech.2009.03.018
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514