| Literature DB >> 19394692 |
Hong-Yun Jia1, Jiang-Xue Wu, Xiao-Feng Zhu, Jie-Min Chen, Shi-Ping Yang, Hai-Jiao Yan, Li Tan, Yi-Xin Zeng, Wenlin Huang.
Abstract
ZD6474 is an orally available, small-molecule tyrosine kinase inhibitor. This study explores the effect of ZD6474 on imatinib-resistant K562 cell lines, which show markedly increased SRC family kinases (SFKs) activity. ZD6474 induces growth arrest and apoptosis of imatinib-resistant and parental K562 cells, as well as inhibition of Src activity and its downstream effectors, the anti-apoptotic Bcl-2 family. ZD6474 treatment also inhibits the activity of STAT3 and reactivation of its activity results in suppression of the anti-tumor effects of SFKs inhibitors. A single oral administration of ZD6474 produced dose-dependent inhibition of imatinib-resistant K562 cells xenograft tumors. These results suggest that clinical assessment of ZD6474 against imatinib-resistant CML is warranted.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19394692 DOI： 10.1016/j.leukres.2009.03.033
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156