| Literature DB >> 19394415 |
Rie Ito1, Naoko Miura, Masaru Ushiro, Migaku Kawaguchi, Hiroko Nakamura, Hirofumi Iguchi, Jun-Ichi Ogino, Manabu Oishi, Nobuyuki Wakui, Yusuke Iwasaki, Koichi Saito, Hiroyuki Nakazawa.
Abstract
The risk assessment of di(2-ethylhexyl)phthalate (DEHP) migration from polyvinyl chloride (PVC) medical devices is an important issue for patients. The aim of this study was to determine DEHP degradation and migration from PVC sheets. To this end, the method for the simultaneous determination of DEHP and its breakdown products (mono(2-ethylhexyl)phthalate (MEHP) and phthalic acid (PA)) was improved. Their migration levels from 0 to 50 kGy gamma-ray irradiated PVC sheets were determined. DEHP migration level decreased in proportion to the dose of gamma-ray irradiation, while MEHP and PA migration levels increased. The hardness and the elastic modulus of PVC sheets were examined, but no clear relationship between DEHP migration and these parameters was observed.Entities:
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Year: 2009 PMID： 19394415 DOI： 10.1016/j.ijpharm.2009.04.019
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875