| Literature DB >> 19394083 |
Gustav Lehne1, Unn-Hilde Grasmo-Wendler, Jeanne-Marie Berner, Leonardo A Meza-Zepeda, Birgitte Lid Adamsen, Aksel Flack, Andrew Reiner, Ole Petter Fraas Clausen, Eivind Hovig, Ola Myklebost.
Abstract
The transmembrane transporter P-glycoprotein (P-gp) encoded by ABCB1, is one major cause for multidrug resistance (MDR). We compared the genomic profile and gene expression pattern of the P-gp positive K562VCR cells with parental P-gp negative K562wt cells. In K562VCR array CGH revealed amplification of ABCB1, ABCB4, ABCB5 and SEMA3D, whereas expression microarrays demonstrated upregulation of stem cell genes (e.g. KIT and HOXB4), anti-apoptotic genes (e.g. IGF1R and CCNG1), and downregulation of pro-apoptotic genes (e.g. CASP4, 6 and 7). Thus, K562VCR cells disclose stem cell characteristics including a range of drug resistance mechanisms possibly attained as a stem cell program switched on en bloc.Entities:
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Year: 2009 PMID： 19394083 DOI： 10.1016/j.leukres.2009.03.028
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156