BACKGROUND: Age-related macular degeneration is the leading cause of blindness, with an increasing incidence as the elderly population expands. OBJECTIVE: In this article we review current therapeutic strategies and discuss possible future targets. METHODS: A review of the literature and ongoing clinical trials was undertaken. RESULTS: Currently, established therapies for neovascular AMD-like photodynamic therapy and anti-VEGF therapies allow stabilization or even improvement of vision. Potential future drugs under development for advanced AMD or its prevention target the signal transduction cascade of different angiogenic molecules. These drugs intervene at different levels of the involved processes including the RNA production and specific protein expression as well as inflammatory, apoptotic, or metabolic processes. CONCLUSION: Combining different strategies targeting angiogenesis, inflammation and apoptosis, or interfering early in--or even prior to--the formation of choroidal neovascularization, may improve the future management of age-related macular degeneration.
BACKGROUND: Age-related macular degeneration is the leading cause of blindness, with an increasing incidence as the elderly population expands. OBJECTIVE: In this article we review current therapeutic strategies and discuss possible future targets. METHODS: A review of the literature and ongoing clinical trials was undertaken. RESULTS: Currently, established therapies for neovascular AMD-like photodynamic therapy and anti-VEGF therapies allow stabilization or even improvement of vision. Potential future drugs under development for advanced AMD or its prevention target the signal transduction cascade of different angiogenic molecules. These drugs intervene at different levels of the involved processes including the RNA production and specific protein expression as well as inflammatory, apoptotic, or metabolic processes. CONCLUSION: Combining different strategies targeting angiogenesis, inflammation and apoptosis, or interfering early in--or even prior to--the formation of choroidal neovascularization, may improve the future management of age-related macular degeneration.
Authors: Salomon-Yves Cohen; Eric H Souied; Michel Weber; Gérard Dupeyron; Gérard de Pouvourville; Michel Lievre; Anne Ponthieux Journal: Graefes Arch Clin Exp Ophthalmol Date: 2010-11-06 Impact factor: 3.117
Authors: Debasish Sen; Elliott D SoRelle; Orly Liba; Roopa Dalal; Yannis M Paulus; Tae-Wan Kim; Darius M Moshfeghi; Adam de la Zerda Journal: J Biomed Opt Date: 2016-06-01 Impact factor: 3.170
Authors: Vincent Daien; Bora M Eldem; James S Talks; Jean-Francois Korobelnik; Paul Mitchell; Robert P Finger; Taiji Sakamoto; Tien Yin Wong; Obaro Evuarherhe; Gemma Carter; Joao Carrasco Journal: BMC Ophthalmol Date: 2019-10-16 Impact factor: 2.209