Literature DB >> 19391107

Mechanism of growth inhibition by MicroRNA 145: the role of the IGF-I receptor signaling pathway.

Gaspare La Rocca1, Margherita Badin, Bin Shi, Shi-Qiong Xu, Tiziana Deangelis, Laura Sepp-Lorenzinoi, Renato Baserga.   

Abstract

MicroRNA 145 (miR145) has been proposed as a tumor suppressor. It was previously shown that miR145 targets the 3' UTR of the insulin receptor substrate-1 (IRS-1) and dramatically inhibits the growth of colon cancer cells. miR145 also targets the type 1 insulin-like growth factor receptor (IGF-IR). We show here that an IRS-1 lacking its 3' UTR is no longer down-regulated by miR145 and rescues colon cancer cells from miR145-induced inhibition of growth. An IGF-IR resistant to miR145 (again by elimination of its 3' UTR) is not down-regulated by miR145 but fails to rescue colon cancer cells from growth inhibition. These and other results, taken together, indicate that down-regulation of IRS-1 plays a significant role in the tumor suppressor activity of miR145.

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Year:  2009        PMID： 19391107     DOI： 10.1002/jcp.21796

Source DB:  PubMed          Journal:  J Cell Physiol        ISSN： 0021-9541            Impact factor:   6.384


  51 in total

1.  MicroRNA-221 inhibits CDKN1C/p57 expression in human colorectal carcinoma.

Authors:  Kai Sun; Wei Wang; Jun-jie Zeng; Cheng-tang Wu; Shang-tong Lei; Guo-xin Li
Journal:  Acta Pharmacol Sin       Date:  2011-01-31       Impact factor: 6.150

2.  Putative tumor suppressor miR-145 inhibits colon cancer cell growth by targeting oncogene Friend leukemia virus integration 1 gene.

Authors:  Jianjun Zhang; Haiyan Guo; He Zhang; Haibo Wang; Guanxiang Qian; Xianqun Fan; Andrew R Hoffman; Ji-Fan Hu; Shengfang Ge
Journal:  Cancer       Date:  2010-08-24       Impact factor: 6.860

3.  IGF1/IGF1R and microRNA let-7e down-regulate each other and modulate proliferation and migration of colorectal cancer cells.

Authors:  Zhenjun Li; Weihuo Pan; Yi Shen; Zhiliang Chen; Lihua Zhang; Yuping Zhang; Quan Luo; Xiaojiang Ying
Journal:  Cell Cycle       Date:  2018-07-18       Impact factor: 4.534

4.  Intravesical treatment of advanced urothelial bladder cancers with oncolytic HSV-1 co-regulated by differentially expressed microRNAs.

Authors:  K-X Zhang; Y Matsui; C Lee; O Osamu; L Skinner; J Wang; A So; P S Rennie; W W Jia
Journal:  Gene Ther       Date:  2016-02-23       Impact factor: 5.250

5.  The potential value of miR-1 and miR-374b as biomarkers for colorectal cancer.

Authors:  Xiaobing Wu; Shuling Li; Xuehu Xu; Shangbiao Wu; Rong Chen; Qingping Jiang; Yong Li; Yuandong Xu
Journal:  Int J Clin Exp Pathol       Date:  2015-03-01

6.  Role of miR-100 in the radioresistance of colorectal cancer cells.

Authors:  Xiao-Dong Yang; Xiao-Hui Xu; Shu-Yu Zhang; Yong Wu; Chun-Gen Xing; Gan Ru; Hong-Tao Xu; Jian-Ping Cao
Journal:  Am J Cancer Res       Date:  2015-01-15       Impact factor: 6.166

7.  Role of Akt2 in regulation of metastasis suppressor 1 expression and colorectal cancer metastasis.

Authors:  E Agarwal; C M Robb; L M Smith; M G Brattain; J Wang; J D Black; S Chowdhury
Journal:  Oncogene       Date:  2017-01-09       Impact factor: 9.867

8.  MicroRNA-145 targets YES and STAT1 in colon cancer cells.

Authors:  Lea H Gregersen; Anders B Jacobsen; Lisa B Frankel; Jiayu Wen; Anders Krogh; Anders H Lund
Journal:  PLoS One       Date:  2010-01-21       Impact factor: 3.240

Review 9.  MicroRNAs in colorectal cancer: translation of molecular biology into clinical application.

Authors:  Ondrej Slaby; Marek Svoboda; Jaroslav Michalek; Rostislav Vyzula
Journal:  Mol Cancer       Date:  2009-11-14       Impact factor: 27.401

10.  Expression and function of the insulin receptor substrate proteins in cancer.

Authors:  Katerina Mardilovich; Shannon L Pankratz; Leslie M Shaw
Journal:  Cell Commun Signal       Date:  2009-06-17       Impact factor: 5.712
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