Literature DB >> 19391009

ACTH therapy in refractory generalized epilepsy.

Veena Kalra1, Suvasini Sharma, Ravindra Arya.   

Abstract

Adrenocorticotropic hormone (ACTH) has a long track record for the treatment of infantile spasms. However, there is paucity of data on the use of ACTH in the treatment of epilepsy beyond infantile spasms. We report the use of ACTH in two children with refractory generalized epilepsy. Both patients responded well. ACTH may be considered as a useful adjunctive therapy in patients with intractable generalized seizures. Side effects and cost however, remain important concerns.

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Year:  2009        PMID： 19391009     DOI： 10.1007/s12098-009-0035-z

Source DB:  PubMed          Journal:  Indian J Pediatr        ISSN： 0019-5456            Impact factor:   1.967


  9 in total

Review 1.  Corticosteroids including ACTH for childhood epilepsy other than epileptic spasms.

Authors:  N A Gayatri; C D Ferrie; H Cross
Journal:  Cochrane Database Syst Rev       Date:  2007-01-24

2.  ACTH therapy for generalized seizures other than spasms.

Authors:  Akihisa Okumura; Takeshi Tsuji; Toru Kato; Jun Natsume; Tamiko Negoro; Kazuyoshi Watanabe
Journal:  Seizure       Date:  2006-06-27       Impact factor: 3.184

3.  Steroids in intractable childhood epilepsy: clinical experience and review of the literature.

Authors:  Helene Verhelst; Paul Boon; Gunnar Buyse; Berten Ceulemans; Marc D'Hooghe; Linda De Meirleir; Danièle Hasaerts; An Jansen; Lieven Lagae; Alfred Meurs; Rudy Van Coster; Kristl Vonck
Journal:  Seizure       Date:  2005-09       Impact factor: 3.184

Review 4.  Neurosteroids and infantile spasms: the deoxycorticosterone hypothesis.

Authors:  Michael A Rogawski; Doodipala S Reddy
Journal:  Int Rev Neurobiol       Date:  2002       Impact factor: 3.230

5.  Effect of ACTH therapy for epileptic spasms without hypsarrhythmia.

Authors:  Hirokazu Oguni; Makoto Funatsuka; Kaori Sasaki; Tae Nakajima; Keisuke Yoshii; Tsutomu Nishimura; Makiko Osawa
Journal:  Epilepsia       Date:  2005-05       Impact factor: 5.864

Review 6.  Neuropeptide-mediated excitability: a key triggering mechanism for seizure generation in the developing brain.

Authors:  T Z Baram; C G Hatalski
Journal:  Trends Neurosci       Date:  1998-11       Impact factor: 13.837

7.  Trial of an ACTH4-9 Analogue (ORG 2766) in children with intractable seizures.

Authors:  K Pentella; D S Bachman; C A Sandman
Journal:  Neuropediatrics       Date:  1982-05       Impact factor: 1.947

Review 8.  Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.

Authors:  M T Mackay; S K Weiss; T Adams-Webber; S Ashwal; D Stephens; K Ballaban-Gill; T Z Baram; M Duchowny; D Hirtz; J M Pellock; W D Shields; S Shinnar; E Wyllie; O C Snead
Journal:  Neurology       Date:  2004-05-25       Impact factor: 9.910

9.  ACTH and prednisone in childhood seizure disorders.

Authors:  O C Snead; J W Benton; G J Myers
Journal:  Neurology       Date:  1983-08       Impact factor: 9.910
  9 in total
  1 in total

1.  Therapeutic Effects of Adrenocorticotropic Hormone ACTH in Children with Severely Intractable Seizure.

Authors:  Jafar Nasiri; Azam Sarajan; Mehri Salari; Maryam Sedghi
Journal:  Iran J Child Neurol       Date:  2017
  1 in total

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