AIM: To investigate which recent infection could have caused the present dengue-like symptoms, in adult patients clinically fulfilling the WHO criteria for dengue, in which serologically were not confirmed for dengue virus infections. METHODS: Prospective study. During an outbreak of dengue (between May 1995 and May 1996) 118 consecutive adults (>13 years) suspected by the WHO 1997 case definition of DF or DHF were investigated. Patients were examined for history of illness, physical and laboratory findings consisting of full blood counts, prothrombin time (PT), activated partial thromboplastin time (aPTT), liver function (bilirubin, ASAT, ALAT), renal function (creatinine), and serological assays included dengue, hantavirus, chikungunya, R. typhi, R. tsutsugamuchi, rubella virus, influenza A virus, and leptospira. RESULTS: In 58 of the total 118 patients, recent dengue virus infection was serologically confirmed. In 20 of the remaining 60 patients, we found serological evidence of another recent infection: hantavirus (5), chikungunya virus (2), R. typhi (5), R. tsutsugamuchi (2), rubella virus (3), influenza A virus (1), and leptospira (2). No evidence for recent infection with any of the mentioned agents was detected in the remaining 40 specimens. CONCLUSION: We conclude that based on clinical characteristics alone, it is not easy to diagnose dengue. Specific laboratory tests to differentiate dengue from other febrile illnesses are needed. Among these, in Indonesia hantavirus infection should be considered as well.
AIM: To investigate which recent infection could have caused the present dengue-like symptoms, in adult patients clinically fulfilling the WHO criteria for dengue, in which serologically were not confirmed for dengue virus infections. METHODS: Prospective study. During an outbreak of dengue (between May 1995 and May 1996) 118 consecutive adults (>13 years) suspected by the WHO 1997 case definition of DF or DHF were investigated. Patients were examined for history of illness, physical and laboratory findings consisting of full blood counts, prothrombin time (PT), activated partial thromboplastin time (aPTT), liver function (bilirubin, ASAT, ALAT), renal function (creatinine), and serological assays included dengue, hantavirus, chikungunya, R. typhi, R. tsutsugamuchi, rubella virus, influenza A virus, and leptospira. RESULTS: In 58 of the total 118 patients, recent dengue virus infection was serologically confirmed. In 20 of the remaining 60 patients, we found serological evidence of another recent infection: hantavirus (5), chikungunya virus (2), R. typhi (5), R. tsutsugamuchi (2), rubella virus (3), influenza A virus (1), and leptospira (2). No evidence for recent infection with any of the mentioned agents was detected in the remaining 40 specimens. CONCLUSION: We conclude that based on clinical characteristics alone, it is not easy to diagnose dengue. Specific laboratory tests to differentiate dengue from other febrile illnesses are needed. Among these, in Indonesia hantavirus infection should be considered as well.
Authors: Mariola Mascarenhas; Sophiya Garasia; Philippe Berthiaume; Tricia Corrin; Judy Greig; Victoria Ng; Ian Young; Lisa Waddell Journal: PLoS One Date: 2018-11-29 Impact factor: 3.240
Authors: Ana Cláudia Pereira Terças-Trettel; Elaine Cristina de Oliveira; Cor Jesus Fernandes Fontes; Alba Valéria Gomes de Melo; Renata Carvalho de Oliveira; Alexandro Guterres; Jorlan Fernandes; Raphael Gomes da Silva; Marina Atanaka; Mariano Martinez Espinosa; Elba Regina Sampaio de Lemos Journal: Int J Environ Res Public Health Date: 2019-05-25 Impact factor: 3.390
Authors: I Made Susila Utama; Nurhayati Lukman; Dewi Dian Sukmawati; Bachti Alisjahbana; Anggraini Alam; Dewi Murniati; I Made Gede Dwi Lingga Utama; Dwiyanti Puspitasari; Herman Kosasih; Ida Laksono; Muhammad Karyana; Mulya Rahma Karyanti; M M D E A H Hapsari; Ninny Meutia; C Jason Liang; Wahyu Nawang Wulan; Chuen-Yen Lau; Ketut Tuti Merati Parwati Journal: PLoS Negl Trop Dis Date: 2019-10-21
Authors: Muhammad Hussein Gasem; Herman Kosasih; Emiliana Tjitra; Bachti Alisjahbana; Muhammad Karyana; Dewi Lokida; Aaron Neal; C Jason Liang; Abu Tholib Aman; Mansyur Arif; Pratiwi Sudarmono; Tuti Parwati Merati; Vivi Lisdawati; Sophia Siddiqui; H Clifford Lane Journal: PLoS Negl Trop Dis Date: 2020-01-10