Literature DB >> 19389552

Salivary biomarkers for the detection of malignant tumors that are remote from the oral cavity.

Lenora R Bigler1, Charles F Streckfus, William P Dubinsky.   

Abstract

Proteomic analyses by mass spectrometry are propelling the field of medical diagnostics forward at unprecedented rates because of its ability reliably to identify proteins that are at the femtomole level in concentration. These advancements have also benefited biomarker research to the point where saliva is now recognized as an excellent diagnostic medium for the detection of malignant tumors that are remote from the oral cavity. Saliva is easy to collect and may provide diagnostic information about a variety of cancers. In particular, proof-of-principle has been demonstrated for salivary biomarker research. This article reviews the literature, discusses the theories associated with saliva-based tumor diagnostics, and presents the current research focused on the use of saliva as a diagnostic medium for the detection of cancer.

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Year:  2009        PMID： 19389552     DOI： 10.1016/j.cll.2009.01.004

Source DB:  PubMed          Journal:  Clin Lab Med        ISSN： 0272-2712            Impact factor:   1.935


  29 in total

1.  A study of salivary lactate dehydrogenase isoenzyme levels in patients with oral leukoplakia and squamous cell carcinoma by gel electrophoresis method.

Authors:  Priya Shirish Joshi; Someshwar Golgire
Journal:  J Oral Maxillofac Pathol       Date:  2014-09

Review 2.  Saliva as a diagnostic fluid.

Authors:  Daniel Malamud
Journal:  Dent Clin North Am       Date:  2011-01

3.  Salivary biomarkers associated with myocardial necrosis: results from an alcohol septal ablation model.

Authors:  Joseph D Foley; J Darrell Sneed; Steven R Steinhubl; Justin R Kolasa; Jeffrey L Ebersole; Yushun Lin; Richard J Kryscio; John T McDevitt; Charles L Campbell; Craig S Miller
Journal:  Oral Surg Oral Med Oral Pathol Oral Radiol       Date:  2012-09-28

Review 4.  Salivary biomarkers in oral squamous cell carcinoma - An insight.

Authors:  T Radhika; Nadeem Jeddy; S Nithya; R M Muthumeenakshi
Journal:  J Oral Biol Craniofac Res       Date:  2016-08-08

5.  Oral fluids that detect cardiovascular disease biomarkers.

Authors:  Joseph D Foley; J Darrell Sneed; Steven R Steinhubl; Justin Kolasa; Jeffrey L Ebersole; Yushun Lin; Richard J Kryscio; John T McDevitt; Charles L Campbell; Craig S Miller
Journal:  Oral Surg Oral Med Oral Pathol Oral Radiol       Date:  2012-08

6.  Discovery and preclinical validation of salivary transcriptomic and proteomic biomarkers for the non-invasive detection of breast cancer.

Authors:  Lei Zhang; Hua Xiao; Scott Karlan; Hui Zhou; Jenny Gross; David Elashoff; David Akin; Xinmin Yan; David Chia; Beth Karlan; David T Wong
Journal:  PLoS One       Date:  2010-12-31       Impact factor: 3.240

7.  Salivary markers for oral cancer detection.

Authors:  Anastasios K Markopoulos; Evangelia Z Michailidou; Georgios Tzimagiorgis
Journal:  Open Dent J       Date:  2010-08-27

Review 8.  Potential applications of human saliva as diagnostic fluid.

Authors:  M Castagnola; P M Picciotti; I Messana; C Fanali; A Fiorita; T Cabras; L Calò; E Pisano; G C Passali; F Iavarone; G Paludetti; E Scarano
Journal:  Acta Otorhinolaryngol Ital       Date:  2011-12       Impact factor: 2.124

Review 9.  Current concepts and future of noninvasive procedures for diagnosing oral squamous cell carcinoma--a systematic review.

Authors:  Esam Omar
Journal:  Head Face Med       Date:  2015-03-25       Impact factor: 2.151

10.  A Comparison of the Proteomic Expression in Pooled Saliva Specimens from Individuals Diagnosed with Ductal Carcinoma of the Breast with and without Lymph Node Involvement.

Authors:  Charles F Streckfus; Karen A Storthz; Lenora Bigler; William P Dubinsky
Journal:  J Oncol       Date:  2009-12-20       Impact factor: 4.375
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