| Literature DB >> 19389452 |
Eunha Shim1, Alison P Galvani.
Abstract
The objective of this study is to estimate the cost-effectiveness of mass vaccination of US infants with the recently available rotavirus vaccine, RotaTeq. We developed a dynamic transmission model of rotavirus to incorporate herd immunity into cost-effectiveness analysis. Our study indicates that a rotavirus vaccination program would prevent about 90% of rotavirus incidence, mortality, hospitalization and emergency department visits annually. We conclude that a universal rotavirus vaccine program in the US would cost $77.30 per case averted from the health care and give a net saving of $80.75 per case averted from the societal perspectives, respectively. The cost per QALY gained was found to be $104,610 when we considered child with one caregiver, making the rotavirus vaccination program a cost-effective intervention.Entities:
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Year: 2009 PMID： 19389452 DOI： 10.1016/j.vaccine.2009.04.030
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641