| Literature DB >> 19388174 |
Abstract
On the basis of biochemical and immunologic studies, a receptor for iC3b with some activities reminiscent of the integrins CD11b and CD11c was defined on the cell wall of clinical and laboratory isolates of Candida albicans. The INT1 gene encodes a protein of 1659 amino acids; the Int1 protein participates in adhesion to epithelial cells in vitro and in vivo. Int1 is essential for hyphal morphogenesis and virulence in a murine model. Recent evidence points to the amino terminus of Int1 as the source of a peptide, Pep263, with superantigen-like activities.Entities:
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Year: 2008 PMID： 19388174 PMCID： PMC2768074 DOI： 10.1016/j.vaccine.2008.11.056
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641