PURPOSE: To develop and implement a method for improved cerebellar tissue classification on the MRI of brain by automatically isolating the cerebellum prior to segmentation. MATERIALS AND METHODS: Dual fast spin echo (FSE) and fluid attenuation inversion recovery (FLAIR) images were acquired on 18 normal volunteers on a 3 T Philips scanner. The cerebellum was isolated from the rest of the brain using a symmetric inverse consistent nonlinear registration of individual brain with the parcellated template. The cerebellum was then separated by masking the anatomical image with individual FLAIR images. Tissues in both the cerebellum and rest of the brain were separately classified using hidden Markov random field (HMRF), a parametric method, and then combined to obtain tissue classification of the whole brain. The proposed method for tissue classification on real MR brain images was evaluated subjectively by two experts. The segmentation results on Brainweb images with varying noise and intensity nonuniformity levels were quantitatively compared with the ground truth by computing the Dice similarity indices. RESULTS: The proposed method significantly improved the cerebellar tissue classification on all normal volunteers included in this study without compromising the classification in remaining part of the brain. The average similarity indices for gray matter (GM) and white matter (WM) in the cerebellum are 89.81 (+/-2.34) and 93.04 (+/-2.41), demonstrating excellent performance of the proposed methodology. CONCLUSION: The proposed method significantly improved tissue classification in the cerebellum. The GM was overestimated when segmentation was performed on the whole brain as a single object.
PURPOSE: To develop and implement a method for improved cerebellar tissue classification on the MRI of brain by automatically isolating the cerebellum prior to segmentation. MATERIALS AND METHODS: Dual fast spin echo (FSE) and fluid attenuation inversion recovery (FLAIR) images were acquired on 18 normal volunteers on a 3 T Philips scanner. The cerebellum was isolated from the rest of the brain using a symmetric inverse consistent nonlinear registration of individual brain with the parcellated template. The cerebellum was then separated by masking the anatomical image with individual FLAIR images. Tissues in both the cerebellum and rest of the brain were separately classified using hidden Markov random field (HMRF), a parametric method, and then combined to obtain tissue classification of the whole brain. The proposed method for tissue classification on real MR brain images was evaluated subjectively by two experts. The segmentation results on Brainweb images with varying noise and intensity nonuniformity levels were quantitatively compared with the ground truth by computing the Dice similarity indices. RESULTS: The proposed method significantly improved the cerebellar tissue classification on all normal volunteers included in this study without compromising the classification in remaining part of the brain. The average similarity indices for gray matter (GM) and white matter (WM) in the cerebellum are 89.81 (+/-2.34) and 93.04 (+/-2.41), demonstrating excellent performance of the proposed methodology. CONCLUSION: The proposed method significantly improved tissue classification in the cerebellum. The GM was overestimated when segmentation was performed on the whole brain as a single object.
Authors: T L Jernigan; S L Archibald; C Fennema-Notestine; A C Gamst; J C Stout; J Bonner; J R Hesselink Journal: Neurobiol Aging Date: 2001 Jul-Aug Impact factor: 4.673
Authors: Minyoung E Sim; In Kyoon Lyoo; Chris C Streeter; Julie Covell; Ofra Sarid-Segal; Domenic A Ciraulo; Minue J Kim; Marc J Kaufman; Deborah A Yurgelun-Todd; Perry F Renshaw Journal: Neuropsychopharmacology Date: 2007-02-14 Impact factor: 7.853
Authors: D R Altmann; B Jasperse; F Barkhof; K Beckmann; M Filippi; L D Kappos; P Molyneux; C H Polman; C Pozzilli; A J Thompson; K Wagner; T A Yousry; D H Miller Journal: Neurology Date: 2008-11-12 Impact factor: 9.910
Authors: C Fennema-Notestine; S L Archibald; M W Jacobson; J Corey-Bloom; J S Paulsen; G M Peavy; A C Gamst; J M Hamilton; D P Salmon; T L Jernigan Journal: Neurology Date: 2004-09-28 Impact factor: 9.910
Authors: Ponnada A Narayana; Yuxiang Zhou; Khader M Hasan; Sushmita Datta; Xiaojun Sun; Jerry S Wolinsky Journal: Mult Scler Date: 2013-07-08 Impact factor: 6.312
Authors: R E Gabr; J A Lincoln; A Kamali; O Arevalo; X Zhang; X Sun; K M Hasan; P A Narayana Journal: AJNR Am J Neuroradiol Date: 2020-10-08 Impact factor: 3.825