OBJECTIVE: Polysialic acid (PSA) is a carbohydrate binding on the neural cell adhesion molecule NCAM and impedes cell-cell interactions. It prevents neural progenitor cell differentiation and promotes their migration. Highly malignant tumours like small cell lung carcinoma (SCLC) also overexpress PSA and this correlates with a negative prognosis. METHODS: Intra-operatively collected biopsies from 30 patients with different astrocytoma grades were immuno-histochemically examined to identify expression of PSA. RESULTS: Astrocytoma grade I and II had 4% PSA expressing cells whereas in grade III and IV the number of PSA expressing cells was 45%. This difference was statistically highly significant. CONCLUSION: In this short communication we show that highly malignant astrocytomas express significantly more PSA compared to less malignant astrocytomas. Cleavage of PSA could be used in future therapeutic approaches.
OBJECTIVE:Polysialic acid (PSA) is a carbohydrate binding on the neural cell adhesion molecule NCAM and impedes cell-cell interactions. It prevents neural progenitor cell differentiation and promotes their migration. Highly malignant tumours like small cell lung carcinoma (SCLC) also overexpress PSA and this correlates with a negative prognosis. METHODS: Intra-operatively collected biopsies from 30 patients with different astrocytoma grades were immuno-histochemically examined to identify expression of PSA. RESULTS:Astrocytoma grade I and II had 4% PSA expressing cells whereas in grade III and IV the number of PSA expressing cells was 45%. This difference was statistically highly significant. CONCLUSION: In this short communication we show that highly malignant astrocytomas express significantly more PSA compared to less malignant astrocytomas. Cleavage of PSA could be used in future therapeutic approaches.
Authors: Annasara Lenman; A Manuel Liaci; Yan Liu; Lars Frängsmyr; Martin Frank; Bärbel S Blaum; Wengang Chai; Iva I Podgorski; Balázs Harrach; Mária Benkő; Ten Feizi; Thilo Stehle; Niklas Arnberg Journal: Proc Natl Acad Sci U S A Date: 2018-04-19 Impact factor: 11.205
Authors: J Bushman; B Mishra; M Ezra; S Gul; C Schulze; S Chaudhury; D Ripoll; A Wallqvist; J Kohn; M Schachner; G Loers Journal: Neuropharmacology Date: 2013-09-22 Impact factor: 5.250
Authors: Katri Mäkelä; Kristiina Nordfors; Jukka Finne; Anne Jokilammi; Timo Paavonen; Hannu Haapasalo; Miikka Korja; Joonas Haapasalo Journal: BMC Cancer Date: 2014-08-28 Impact factor: 4.430