PURPOSE: To investigate changes in corneal topography and morphology in human eyes wearing orthokeratology (OK) lenses for overnight and over a 5-year period. MATERIALS AND METHODS:Fifty-six adults with moderate myopia were assigned to 2 groups based on age matching: 5-year lens wear (n = 26, 51 eyes) and 1-night lens wear (n = 30, 60 eyes). All subjects wore reverse-geometry OK lenses with the eyes before 1-night lens wear serving as a control to both the groups. Visual acuity, slit-lamp biomicroscopy, confocal microscopy, and corneal topography were assessed before and after lens wear. RESULTS:Visual acuity was improved satisfactorily with flattening of the central cornea in both lens wear groups. Corneal thickness increased extensively in the 1-night lens wear group but only paracentrally in the 5-year lens wear group. Central epithelial thinning with a decreased density of the basal cells was only observed in the 5-year group. Keratocyte density was reduced throughout the entire corneal thickness for the 2 groups. Endothelium was normal in density and morphology for the 2 groups. CONCLUSIONS: Short-term and long-term OK lens wear can effectively correct myopia by flattening the cornea. The flattened cornea in the short-term lens wear is mainly because of the thickening of the midperipheral cornea. In the long-term lens wear, however, this change is associated with thickening of the midperipheral cornea and thinning of the central corneal epithelium.
RCT Entities:
PURPOSE: To investigate changes in corneal topography and morphology in human eyes wearing orthokeratology (OK) lenses for overnight and over a 5-year period. MATERIALS AND METHODS: Fifty-six adults with moderate myopia were assigned to 2 groups based on age matching: 5-year lens wear (n = 26, 51 eyes) and 1-night lens wear (n = 30, 60 eyes). All subjects wore reverse-geometry OK lenses with the eyes before 1-night lens wear serving as a control to both the groups. Visual acuity, slit-lamp biomicroscopy, confocal microscopy, and corneal topography were assessed before and after lens wear. RESULTS: Visual acuity was improved satisfactorily with flattening of the central cornea in both lens wear groups. Corneal thickness increased extensively in the 1-night lens wear group but only paracentrally in the 5-year lens wear group. Central epithelial thinning with a decreased density of the basal cells was only observed in the 5-year group. Keratocyte density was reduced throughout the entire corneal thickness for the 2 groups. Endothelium was normal in density and morphology for the 2 groups. CONCLUSIONS: Short-term and long-term OK lens wear can effectively correct myopia by flattening the cornea. The flattened cornea in the short-term lens wear is mainly because of the thickening of the midperipheral cornea. In the long-term lens wear, however, this change is associated with thickening of the midperipheral cornea and thinning of the central corneal epithelium.
Authors: Jimmy S H Tse; Jimmy K W Cheung; Gigi T K Wong; Thomas C Lam; Kai Yip Choi; Katherine H Y So; Christie D M Lam; Andes Y H Sze; Angel C K Wong; Gigi M C Yee; Henry H L Chan Journal: Transl Vis Sci Technol Date: 2021-09-01 Impact factor: 3.283