Literature DB >> 19386608

Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6.

Keisuke Yanagida1, Kayo Masago, Hiroki Nakanishi, Yasuyuki Kihara, Fumie Hamano, Yoko Tajima, Ryo Taguchi, Takao Shimizu, Satoshi Ishii.   

Abstract

p2y5 is an orphan G protein-coupled receptor that is closely related to the fourth lysophosphatidic acid (LPA) receptor, LPA4. Here we report that p2y5 is a novel LPA receptor coupling to the G13-Rho signaling pathway. "LPA receptor-null" RH7777 and B103 cells exogenously expressing p2y5 showed [3H]LPA binding, LPA-induced [35S]guanosine 5'-3-O-(thio)triphosphate binding, Rho-dependent alternation of cellular morphology, and Gs/13 chimeric protein-mediated cAMP accumulation. LPA-induced contraction of human umbilical vein endothelial cells was suppressed by small interfering RNA knockdown of endogenously expressed p2y5. We also found that 2-acyl-LPA had higher activity to p2y5 than 1-acyl-LPA. A recent study has suggested that p2y5 is an LPA receptor essential for human hair growth. We confirmed that p2y5 is a functional LPA receptor and propose to designate this receptor LPA6.

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Year:  2009        PMID： 19386608      PMCID： PMC2719412          DOI： 10.1074/jbc.M808506200

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  60 in total

Review 1.  Lysophospholipid signaling in the function and pathology of the reproductive system.

Authors:  Xiaoqin Ye
Journal:  Hum Reprod Update       Date:  2008-06-17       Impact factor: 15.610

2.  Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair.

Authors:  Yutaka Shimomura; Muhammad Wajid; Yoshiyuki Ishii; Lawrence Shapiro; Lynn Petukhova; Derek Gordon; Angela M Christiano
Journal:  Nat Genet       Date:  2008-02-24       Impact factor: 38.330

3.  G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth.

Authors:  Sandra M Pasternack; Ivar von Kügelgen; Khalid Al Aboud; Young-Ae Lee; Franz Rüschendorf; Katrin Voss; Axel M Hillmer; Gerhard J Molderings; Thomas Franz; Alfredo Ramirez; Peter Nürnberg; Markus M Nöthen; Regina C Betz
Journal:  Nat Genet       Date:  2008-02-24       Impact factor: 38.330

4.  Genome-wide linkage analysis of an autosomal recessive hypotrichosis identifies a novel P2RY5 mutation.

Authors:  Lynn Petukhova; Edilson C Sousa; Amalia Martinez-Mir; Anna Vitebsky; Lina G Dos Santos; Lawrence Shapiro; Chad Haynes; Derek Gordon; Yutaka Shimomura; Angela M Christiano
Journal:  Genomics       Date:  2008-09-13       Impact factor: 5.736

Review 5.  Roles of lysophosphatidic acid in cardiovascular physiology and disease.

Authors:  Susan S Smyth; Hsin-Yuan Cheng; Sumitra Miriyala; Manikandan Panchatcharam; Andrew J Morris
Journal:  Biochim Biophys Acta       Date:  2008-06-10

Review 6.  Two pathways for lysophosphatidic acid production.

Authors:  Junken Aoki; Asuka Inoue; Shinichi Okudaira
Journal:  Biochim Biophys Acta       Date:  2008-06-24

7.  Lysophosphatidic acid regulates inflammation-related genes in human endothelial cells through LPA1 and LPA3.

Authors:  Chi-Iou Lin; Chiung-Nien Chen; Po-Wei Lin; King-Jen Chang; Fong-Jou Hsieh; Hsinyu Lee
Journal:  Biochem Biophys Res Commun       Date:  2007-10-01       Impact factor: 3.575

8.  A novel deletion mutation in LIPH gene causes autosomal recessive hypotrichosis (LAH2).

Authors:  M Jelani; N Wasif; G Ali; Ms Chishti; W Ahmad
Journal:  Clin Genet       Date:  2008-04-28       Impact factor: 4.438

9.  Molecular dissection of G protein preference using Gsalpha chimeras reveals novel ligand signaling of GPCRs.

Authors:  Shih-Han Hsu; Ching-Wei Luo
Journal:  Am J Physiol Endocrinol Metab       Date:  2007-07-24       Impact factor: 4.310

10.  Novel mutations in G protein-coupled receptor gene (P2RY5) in families with autosomal recessive hypotrichosis (LAH3).

Authors:  Zahid Azeem; Musharraf Jelani; Gul Naz; Muhammad Tariq; Naveed Wasif; Syed Kamran-Ul-Hassan Naqvi; Muhammad Ayub; Masoom Yasinzai; Muhammad Amin-Ud-Din; Abdul Wali; Ghazanfar Ali; Muhammad Salman Chishti; Wasim Ahmad
Journal:  Hum Genet       Date:  2008-05-07       Impact factor: 4.132
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  81 in total

1.  Lysophosphatidic acid activates lipogenic pathways and de novo lipid synthesis in ovarian cancer cells.

Authors:  Abir Mukherjee; Jinhua Wu; Suzanne Barbour; Xianjun Fang
Journal:  J Biol Chem       Date:  2012-06-03       Impact factor: 5.157

2.  Stimulatory actions of lysophosphatidic acid on mouse ATDC5 chondroprogenitor cells.

Authors:  Ryota Itoh; Shigenori Miura; Aki Takimoto; Shunya Kondo; Hiroko Sano; Yuji Hiraki
Journal:  J Bone Miner Metab       Date:  2010-05-11       Impact factor: 2.626

Review 3.  Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors.

Authors:  Victoria A Blaho; Timothy Hla
Journal:  Chem Rev       Date:  2011-09-22       Impact factor: 60.622

Review 4.  Insights into the pharmacological relevance of lysophospholipid receptors.

Authors:  Tetsuji Mutoh; Richard Rivera; Jerold Chun
Journal:  Br J Pharmacol       Date:  2012-02       Impact factor: 8.739

Review 5.  International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂.

Authors:  R G Pertwee; A C Howlett; M E Abood; S P H Alexander; V Di Marzo; M R Elphick; P J Greasley; H S Hansen; G Kunos; K Mackie; R Mechoulam; R A Ross
Journal:  Pharmacol Rev       Date:  2010-12       Impact factor: 25.468

Review 6.  International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature.

Authors:  Jerold Chun; Timothy Hla; Kevin R Lynch; Sarah Spiegel; Wouter H Moolenaar
Journal:  Pharmacol Rev       Date:  2010-12       Impact factor: 25.468

Review 7.  Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors.

Authors:  Dong-Soon Im
Journal:  Acta Pharmacol Sin       Date:  2010-08-23       Impact factor: 6.150

8.  Chemical Proteomic Profiling of Lysophosphatidic Acid-Binding Proteins.

Authors:  Xuejiao Dong; Linfeng Gao; Jikui Song; Yinsheng Wang
Journal:  Anal Chem       Date:  2019-11-27       Impact factor: 6.986

9.  Gintonin, newly identified compounds from ginseng, is novel lysophosphatidic acids-protein complexes and activates G protein-coupled lysophosphatidic acid receptors with high affinity.

Authors:  Sung Hee Hwang; Tae-Joon Shin; Sun-Hye Choi; Hee-Jung Cho; Byung-Hwan Lee; Mi Kyung Pyo; Jun-Ho Lee; Jiyeon Kang; Hyeon-Joong Kim; Chan-Woo Park; Ho-Chul Shin; Seung-Yeol Nah
Journal:  Mol Cells       Date:  2012-02       Impact factor: 5.034

Review 10.  Lysophosphatidic acid (LPA) signaling in vertebrate reproduction.

Authors:  Xiaoqin Ye; Jerold Chun
Journal:  Trends Endocrinol Metab       Date:  2010-01       Impact factor: 12.015
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