Literature DB >> 19386495

Efficient synthesis of Idraparinux, the anticoagulant pentasaccharide.

Chen Chen1, Biao Yu.   

Abstract

An efficient [DEF+GH] route was developed to the synthesis of Idraparinux, which is a fully O-sulfated, O-methylated mimic of the unique Antithrombin III binding domain of heparin.

Entities:  

Mesh:

Substances:

Year:  2009        PMID: 19386495     DOI: 10.1016/j.bmcl.2009.03.155

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  4 in total

1.  Chemical Sulfation of Small Molecules - Advances and Challenges.

Authors:  Rami A Al-Horani; Umesh R Desai
Journal:  Tetrahedron       Date:  2010-04-17       Impact factor: 2.457

Review 2.  Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: an update for 2009-2010.

Authors:  David J Harvey
Journal:  Mass Spectrom Rev       Date:  2014-05-26       Impact factor: 10.946

3.  Modular synthesis of heparan sulfate oligosaccharides for structure-activity relationship studies.

Authors:  Sailaja Arungundram; Kanar Al-Mafraji; Jinkeng Asong; Franklin E Leach; I Jonathan Amster; Andre Venot; Jeremy E Turnbull; Geert-Jan Boons
Journal:  J Am Chem Soc       Date:  2009-12-02       Impact factor: 15.419

4.  Tailored design and synthesis of heparan sulfate oligosaccharide analogues using sequential one-pot multienzyme systems.

Authors:  Yi Chen; Yanhong Li; Hai Yu; Go Sugiarto; Vireak Thon; Joel Hwang; Li Ding; Liana Hie; Xi Chen
Journal:  Angew Chem Int Ed Engl       Date:  2013-09-13       Impact factor: 15.336

  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.