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Literature DB >> 19384330

Cardiovascular risk and management in chronic kidney disease.

Abstract

Chronic kidney disease (CKD) is associated with accelerated progression of cardiovascular disease, perhaps because patients with CKD have a high burden of traditional cardiovascular risk factors in addition to a range of nontraditional risk factors such as inflammation and abnormal metabolism of calcium and phosphate. Although the cardiovascular burden of CKD is well documented, potentially beneficial therapies are sometimes underused in patients with stage 3-4 CKD and are rarely studied in patients on dialysis. In this Review, we describe the epidemiology of cardiovascular disease in patients with stage 3-5 CKD (excluding kidney transplant recipients) and outline cardiovascular risk factors that are relevant in this population; we then discuss the implications of this knowledge for the optimal management of cardiovascular risk in this setting. Finally, we highlight opportunities for further research.

Entities: Chemical Disease Species

Mesh：

Year: 2009 PMID： 19384330 DOI： 10.1038/nrneph.2009.42

Source DB: PubMed Journal: Nat Rev Nephrol ISSN： 1759-5061 Impact factor: 28.314

102 in total

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Journal: Circulation Date: 2000-12-12 Impact factor: 29.690

6. The Best Pharmaceuticals for Children Act of 2002: the rise of the voluntary incentive structure and congressional refusal to require pediatric testing.

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Journal: Harvard J Legis Date: 2003

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Journal: Hypertension Date: 1989-05 Impact factor: 10.190

10. Association between cholesterol level and mortality in dialysis patients: role of inflammation and malnutrition.

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Journal: Clin J Am Soc Nephrol Date: 2011-09-01 Impact factor: 8.237

3. Managing cardiovascular risk in people with chronic kidney disease: a review of the evidence from randomized controlled trials.

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Review 4. Arterial stiffness and increased cardiovascular risk in chronic kidney disease.

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Journal: Int Urol Nephrol Date: 2015-05-20 Impact factor: 2.370

5. Urea-induced ROS cause endothelial dysfunction in chronic renal failure.

Authors: Maria D'Apolito; Xueliang Du; Daniela Pisanelli; Massimo Pettoello-Mantovani; Angelo Campanozzi; Ferdinando Giacco; Angela Bruna Maffione; Anna Laura Colia; Michael Brownlee; Ida Giardino
Journal: Atherosclerosis Date: 2015-01-31 Impact factor: 5.162