GOAL: To find out the role of family members in the Helicobacter pylori infection in childhood by investigating the incidence of infection within families of H. pylori-infected children. BACKGROUND: H. pylori infection is usually acquired in early childhood and possibly family members are the main source of infection. STUDY: One hundred consecutive children with upper gastrointestinal symptoms, without previous H. pylori eradication treatment were prospectively studied by gastroscopy and C-urea breath test. Simultaneously, all family members were studied by C-urea breath test regardless of earlier eradication treatment for H. pylori infection. The age of children and their parents, socioeconomic status, parents' education, and living conditions were recorded. RESULTS: Forty-four index symptomatic children were infected by H. pylori. No statistical difference was found concerning demographic factors, between H. pylori-positive and H. pylori-negative index children except age, which was higher in the H. pylori-infected children (P=0.009). In all H. pylori-positive and in 71.4% of the negative index children, at least 1 more family member was infected (P<0.001), always including a parent in the H. pylori-positive, compared with 69.6% in the H. pylori-negative group (P<0.001). The percentage of infected siblings, mothers and fathers was higher in H. pylori-infected index children (P<0.001, P=0.001, and P=0.035, respectively). CONCLUSIONS: The prevalence of H. pylori infection is significantly higher among families of infected index children. The presence of at least 1 infected family member in all H. pylori-positive index children suggests that the family could be the main source of H. pylori infection in children.
GOAL: To find out the role of family members in the Helicobacter pyloriinfection in childhood by investigating the incidence of infection within families of H. pylori-infected children. BACKGROUND:H. pyloriinfection is usually acquired in early childhood and possibly family members are the main source of infection. STUDY: One hundred consecutive children with upper gastrointestinal symptoms, without previous H. pylori eradication treatment were prospectively studied by gastroscopy and C-urea breath test. Simultaneously, all family members were studied by C-urea breath test regardless of earlier eradication treatment for H. pyloriinfection. The age of children and their parents, socioeconomic status, parents' education, and living conditions were recorded. RESULTS: Forty-four index symptomatic children were infected by H. pylori. No statistical difference was found concerning demographic factors, between H. pylori-positive and H. pylori-negative index children except age, which was higher in the H. pylori-infected children (P=0.009). In all H. pylori-positive and in 71.4% of the negative index children, at least 1 more family member was infected (P<0.001), always including a parent in the H. pylori-positive, compared with 69.6% in the H. pylori-negative group (P<0.001). The percentage of infected siblings, mothers and fathers was higher in H. pylori-infected index children (P<0.001, P=0.001, and P=0.035, respectively). CONCLUSIONS: The prevalence of H. pyloriinfection is significantly higher among families of infected index children. The presence of at least 1 infected family member in all H. pylori-positive index children suggests that the family could be the main source of H. pyloriinfection in children.
Authors: A Giannakopoulos; A Logothetis; J Panayiotou; K Van-Vliet; I Orfanou; E Roma-Giannikou Journal: Hippokratia Date: 2010-10 Impact factor: 0.471
Authors: Eyad Altamimi; Noor Alsharkhat; Afnan AlJawarneh; Moh D Rawhi Abu Hamad; Anas Abu Assi; Sarah Alawneh; Majd Al-Ahmad Journal: Heliyon Date: 2020-07-20
Authors: Lyana Rodrigues Lima; Adilson José De Almeida; Renata dos Santos Tourinho; Bárbara Hasselmann; Lia Laura Lewis Ximenez; Vanessa Salete De Paula Journal: PLoS One Date: 2014-07-22 Impact factor: 3.240