Literature DB >> 19383829

IRF4: Immunity. Malignancy! Therapy?

Arthur L Shaffer1, N C Tolga Emre, Paul B Romesser, Louis M Staudt.   

Abstract

IRF4, a member of the Interferon Regulatory Factor (IRF) family of transcription factors, is expressed in cells of the immune system, where it transduces signals from various receptors to activate or repress gene expression. IRF4 expression is a key regulator of several steps in lymphoid-, myeloid-, and dendritic-cell differentiation, including the differentiation of mature B cells into antibody-secreting plasma cells. IRF4 expression is also associated with many lymphoid malignancies, with recent evidence pointing to an essential role in multiple myeloma, a malignancy of plasma cells. Interference with IRF4 expression is lethal to multiple myeloma cells, irrespective of their genetic etiology, making IRF4 an "Achilles' heel" that may be exploited therapeutically.

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Year:  2009        PMID： 19383829      PMCID： PMC2790720          DOI： 10.1158/1078-0432.CCR-08-1845

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


  87 in total

1.  Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers.

Authors:  A L Brass; A Q Zhu; H Singh
Journal:  EMBO J       Date:  1999-02-15       Impact factor: 11.598

2.  Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling.

Authors:  Lloyd T Lam; R Eric Davis; Jackie Pierce; Michael Hepperle; Yajun Xu; Maria Hottelet; Yuhua Nong; Danyi Wen; Julian Adams; Lenny Dang; Louis M Staudt
Journal:  Clin Cancer Res       Date:  2005-01-01       Impact factor: 12.531

3.  Differential expression and distinct functions of IFN regulatory factor 4 and IFN consensus sequence binding protein in macrophages.

Authors:  S Marecki; M L Atchison; M J Fenton
Journal:  J Immunol       Date:  1999-09-01       Impact factor: 5.422

4.  IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity.

Authors:  Tomohiko Tamura; Prafullakumar Tailor; Kunihiro Yamaoka; Hee Jeong Kong; Hideki Tsujimura; John J O'Shea; Harinder Singh; Keiko Ozato
Journal:  J Immunol       Date:  2005-03-01       Impact factor: 5.422

5.  PU.1/Pip and basic helix loop helix zipper transcription factors interact with binding sites in the CD20 promoter to help confer lineage- and stage-specific expression of CD20 in B lymphocytes.

Authors:  A Himmelmann; A Riva; G L Wilson; B P Lucas; C Thevenin; J H Kehrl
Journal:  Blood       Date:  1997-11-15       Impact factor: 22.113

6.  Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells.

Authors:  Jose M Polo; Tania Dell'Oso; Stella Maris Ranuncolo; Leandro Cerchietti; David Beck; Gustavo F Da Silva; Gilbert G Prive; Jonathan D Licht; Ari Melnick
Journal:  Nat Med       Date:  2004-11-07       Impact factor: 53.440

Review 7.  The biology of human lymphoid malignancies revealed by gene expression profiling.

Authors:  Louis M Staudt; Sandeep Dave
Journal:  Adv Immunol       Date:  2005       Impact factor: 3.543

8.  Tracking CD40 signaling during germinal center development.

Authors:  Katia Basso; Ulf Klein; Huifeng Niu; Gustavo A Stolovitzky; Yuhai Tu; Andrea Califano; Giorgio Cattoretti; Riccardo Dalla-Favera
Journal:  Blood       Date:  2004-08-26       Impact factor: 22.113

9.  p48/STAT-1alpha-containing complexes play a predominant role in induction of IFN-gamma-inducible protein, 10 kDa (IP-10) by IFN-gamma alone or in synergy with TNF-alpha.

Authors:  S Majumder; L Z Zhou; P Chaturvedi; G Babcock; S Aras; R M Ransohoff
Journal:  J Immunol       Date:  1998-11-01       Impact factor: 5.422

10.  Transcription factor Pip can enhance DNA binding by E47, leading to transcriptional synergy involving multiple protein domains.

Authors:  S Nagulapalli; M L Atchison
Journal:  Mol Cell Biol       Date:  1998-08       Impact factor: 4.272
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  80 in total

Review 1.  Transcriptional programming of the dendritic cell network.

Authors:  Gabrielle T Belz; Stephen L Nutt
Journal:  Nat Rev Immunol       Date:  2012-01-25       Impact factor: 53.106

Review 2.  Oncogenic activation of NF-kappaB.

Authors:  Louis M Staudt
Journal:  Cold Spring Harb Perspect Biol       Date:  2010-04-21       Impact factor: 10.005

3.  Responsiveness of cytogenetically discrete human myeloma cell lines to lenalidomide: lack of correlation with cereblon and interferon regulatory factor 4 expression levels.

Authors:  Alexandra J Greenberg; Denise K Walters; Shaji K Kumar; S Vincent Rajkumar; Diane F Jelinek
Journal:  Eur J Haematol       Date:  2013-09-17       Impact factor: 2.997

4.  The oncogenic transcription factor IRF4 is regulated by a novel CD30/NF-κB positive feedback loop in peripheral T-cell lymphoma.

Authors:  Rebecca L Boddicker; N Sertac Kip; Xiaoming Xing; Yu Zeng; Zhi-Zhang Yang; Jeong-Heon Lee; Luciana L Almada; Sherine F Elsawa; Ryan A Knudson; Mark E Law; Rhett P Ketterling; Julie M Cunningham; Yanhong Wu; Matthew J Maurer; Megan M O'Byrne; James R Cerhan; Susan L Slager; Brian K Link; Julie C Porcher; Deanna M Grote; Diane F Jelinek; Ahmet Dogan; Stephen M Ansell; Martin E Fernandez-Zapico; Andrew L Feldman
Journal:  Blood       Date:  2015-04-01       Impact factor: 22.113

Review 5.  IRF7: activation, regulation, modification and function.

Authors:  S Ning; J S Pagano; G N Barber
Journal:  Genes Immun       Date:  2011-04-14       Impact factor: 2.676

Review 6.  The molecular pathogenesis of chronic lymphocytic leukaemia.

Authors:  Giulia Fabbri; Riccardo Dalla-Favera
Journal:  Nat Rev Cancer       Date:  2016-03       Impact factor: 60.716

Review 7.  Malignant pirates of the immune system.

Authors:  Lixin Rui; Roland Schmitz; Michele Ceribelli; Louis M Staudt
Journal:  Nat Immunol       Date:  2011-09-20       Impact factor: 25.606

8.  The 7p15.3 (rs4487645) association for multiple myeloma shows strong allele-specific regulation of the MYC-interacting gene CDCA7L in malignant plasma cells.

Authors:  Niels Weinhold; Tobias Meissner; David C Johnson; Anja Seckinger; Jérôme Moreaux; Asta Försti; Bowang Chen; Jolanta Nickel; Daniel Chubb; Andrew C Rawstron; Chi Doughty; Nasrin B Dahir; Dil B Begum; Kwee Young; Brian A Walker; Per Hoffmann; Marcus M Nöthen; Faith E Davies; Bernard Klein; Hartmut Goldschmidt; Gareth J Morgan; Richard S Houlston; Dirk Hose; Kari Hemminki
Journal:  Haematologica       Date:  2014-12-05       Impact factor: 9.941

9.  Phenotypes and distribution of mucosal memory B-cell populations in the SIV/SHIV rhesus macaque model.

Authors:  Thorsten Demberg; Venkatramanan Mohanram; David Venzon; Marjorie Robert-Guroff
Journal:  Clin Immunol       Date:  2014-05-09       Impact factor: 3.969

10.  Role of selected genetic variants in lung cancer risk in African Americans.

Authors:  Margaret R Spitz; Christopher I Amos; Susan Land; Xifeng Wu; Qiong Dong; Angela S Wenzlaff; Ann G Schwartz
Journal:  J Thorac Oncol       Date:  2013-04       Impact factor: 15.609
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