Literature DB >> 19383550

G2A and LPC: regulatory functions in immunity.

Janusz H Kabarowski1.   

Abstract

The G2A receptor was originally identified by virtue of its transcriptional induction in murine B lymphoid cells in response to oncogenic transformation and treatment with various DNA-damaging agents. While preliminary characterization of cellular responses to G2A overexpression in fibroblastic cell lines suggested that this receptor may negatively regulate cell growth under conditions of proliferative and genotoxic stress, subsequent studies driven by the discovery of lysophosphatidylcholine (LPC) as a regulator of G2A signaling in immunoregulatory cells point to an important role for this receptor in innate and adaptive immunity.

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Year:  2009        PMID： 19383550      PMCID： PMC2740801          DOI： 10.1016/j.prostaglandins.2009.04.007

Source DB:  PubMed          Journal:  Prostaglandins Other Lipid Mediat        ISSN： 1098-8823            Impact factor:   3.072


  84 in total

1.  Lysophosphatidylcholine modulates neutrophil oxidant production through elevation of cyclic AMP.

Authors:  Phoebe Lin; Emily J Welch; Xiao-Pei Gao; Asrar B Malik; Richard D Ye
Journal:  J Immunol       Date:  2005-03-01       Impact factor: 5.422

2.  Lysophosphatidylcholine-induced surface redistribution regulates signaling of the murine G protein-coupled receptor G2A.

Authors:  Li Wang; Caius G Radu; Li V Yang; Laurent A Bentolila; Mireille Riedinger; Owen N Witte
Journal:  Mol Biol Cell       Date:  2005-02-23       Impact factor: 4.138

3.  The phosphatidylcholine/lysophosphatidylcholine ratio in human plasma is an indicator of the severity of rheumatoid arthritis: investigations by 31P NMR and MALDI-TOF MS.

Authors:  Beate Fuchs; Jürgen Schiller; Ulf Wagner; Holm Häntzschel; Klaus Arnold
Journal:  Clin Biochem       Date:  2005-10       Impact factor: 3.281

4.  Loss of G2A promotes macrophage accumulation in atherosclerotic lesions of low density lipoprotein receptor-deficient mice.

Authors:  Brian W Parks; Ginger P Gambill; Aldons J Lusis; Janusz H S Kabarowski
Journal:  J Lipid Res       Date:  2005-04-16       Impact factor: 5.922

5.  Secretory phospholipases A2 induce neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor.

Authors:  Yutaka Ikeno; Naoko Konno; So-hyun Cheon; Angelo Bolchi; Simone Ottonello; Katsuhiko Kitamoto; Manabu Arioka
Journal:  J Biol Chem       Date:  2005-05-31       Impact factor: 5.157

6.  Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I.

Authors:  Jenelle M Timmins; Ji-Young Lee; Elena Boudyguina; Kimberly D Kluckman; Liam R Brunham; Anny Mulya; Abraham K Gebre; Jonathan M Coutinho; Perry L Colvin; Thomas L Smith; Michael R Hayden; Nobuyo Maeda; John S Parks
Journal:  J Clin Invest       Date:  2005-04-07       Impact factor: 14.808

7.  Suppression of HMGB1 release by stearoyl lysophosphatidylcholine:an additional mechanism for its therapeutic effects in experimental sepsis.

Authors:  Guoqian Chen; Jianhua Li; Xiaoling Qiang; Christopher J Czura; Mahendar Ochani; Kanta Ochani; Luis Ulloa; Huan Yang; Kevin J Tracey; Ping Wang; Andrew E Sama; Haichao Wang
Journal:  J Lipid Res       Date:  2005-02-01       Impact factor: 5.922

Review 8.  The role of IgM antibodies in the recognition and clearance of apoptotic cells.

Authors:  YuFeng Peng; Robert Kowalewski; SunJung Kim; Keith B Elkon
Journal:  Mol Immunol       Date:  2005-01-16       Impact factor: 4.407

Review 9.  New insights into the regulation of HDL metabolism and reverse cholesterol transport.

Authors:  Gary F Lewis; Daniel J Rader
Journal:  Circ Res       Date:  2005-06-24       Impact factor: 17.367

10.  Differential hydrolysis of molecular species of lipoprotein phosphatidylcholine by groups IIA, V and X secretory phospholipases A2.

Authors:  W Pruzanski; L Lambeau; M Lazdunsky; W Cho; J Kopilov; A Kuksis
Journal:  Biochim Biophys Acta       Date:  2005-09-05
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  53 in total

1.  Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis.

Authors:  Peiwen Chen; Hao Zuo; Hu Xiong; Matthew J Kolar; Qian Chu; Alan Saghatelian; Daniel J Siegwart; Yihong Wan
Journal:  Proc Natl Acad Sci U S A       Date:  2017-01-03       Impact factor: 11.205

2.  G2A Protects Mice against Sepsis by Modulating Kupffer Cell Activation: Cooperativity with Adenosine Receptor 2b.

Authors:  Hong-Mei Li; Ji Hye Jang; Jun-Sub Jung; Jiseon Shin; Chul O Park; Yeon-Ja Kim; Won-Gyun Ahn; Ju-Suk Nam; Chang-Won Hong; Jongho Lee; Yu-Jin Jung; Jiang-Fan Chen; Katya Ravid; H Thomas Lee; Won-Ki Huh; Janusz H Kabarowski; Dong-Keun Song
Journal:  J Immunol       Date:  2018-12-10       Impact factor: 5.422

3.  Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132.

Authors:  Jamie L Lahvic; Michelle Ammerman; Pulin Li; Megan C Blair; Emma R Stillman; Eva M Fast; Anne L Robertson; Constantina Christodoulou; Julie R Perlin; Song Yang; Nan Chiang; Paul C Norris; Madeleine L Daily; Shelby E Redfield; Iris T Chan; Mona Chatrizeh; Michael E Chase; Olivia Weis; Yi Zhou; Charles N Serhan; Leonard I Zon
Journal:  Proc Natl Acad Sci U S A       Date:  2018-08-23       Impact factor: 11.205

4.  G2A Signaling Dampens Colitic Inflammation via Production of IFN-γ.

Authors:  S Courtney Frasch; Eóin N McNamee; Douglas Kominsky; Paul Jedlicka; Claudia Jakubzick; Karin Zemski Berry; Matthias Mack; Glenn T Furuta; James J Lee; Peter M Henson; Sean P Colgan; Donna L Bratton
Journal:  J Immunol       Date:  2016-07-08       Impact factor: 5.422

5.  Neutrophils regulate tissue Neutrophilia in inflammation via the oxidant-modified lipid lysophosphatidylserine.

Authors:  S Courtney Frasch; Ruby F Fernandez-Boyanapalli; Karin A Zemski Berry; Robert C Murphy; Christina C Leslie; Jerry A Nick; Peter M Henson; Donna L Bratton
Journal:  J Biol Chem       Date:  2013-01-05       Impact factor: 5.157

Review 6.  Emerging roles for lysophosphatidylserine in resolution of inflammation.

Authors:  S Courtney Frasch; Donna L Bratton
Journal:  Prog Lipid Res       Date:  2012-03-29       Impact factor: 16.195

7.  Signaling via macrophage G2A enhances efferocytosis of dying neutrophils by augmentation of Rac activity.

Authors:  S Courtney Frasch; Ruby F Fernandez-Boyanapalli; Karin Zemski Berry; Christina C Leslie; Joseph V Bonventre; Robert C Murphy; Peter M Henson; Donna L Bratton
Journal:  J Biol Chem       Date:  2011-02-04       Impact factor: 5.157

Review 8.  Accessing Bioactive Natural Products from the Human Microbiome.

Authors:  Aleksandr Milshteyn; Dominic A Colosimo; Sean F Brady
Journal:  Cell Host Microbe       Date:  2018-06-13       Impact factor: 21.023

9.  Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist.

Authors:  Louis J Cohen; Hahk-Soo Kang; John Chu; Yun-Han Huang; Emma A Gordon; Boojala Vijay B Reddy; Melinda A Ternei; Jeffrey W Craig; Sean F Brady
Journal:  Proc Natl Acad Sci U S A       Date:  2015-08-17       Impact factor: 11.205

10.  CD36, but not G2A, modulates efferocytosis, inflammation, and fibrosis following bleomycin-induced lung injury.

Authors:  Brian W Parks; Leland L Black; Kurt A Zimmerman; Allison E Metz; Chad Steele; Joanne E Murphy-Ullrich; Janusz H Kabarowski
Journal:  J Lipid Res       Date:  2013-02-06       Impact factor: 5.922
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